Table 1 Demographic and clinical data of study population

Age

72.53±7.71

71.72±7.26

74.50±8.41

<0.001

Sex (M/F)

250/195

174/142

76/53

0.458

Education

16.18±2.63

16.38±2.61

15.68±2.67

0.012

APOE 4 (carrier/non-carrier)

246/199

160/156

86/43

0.002

CSF biomarkers

 Aβ₄₂ (pg/ml)

160.81±50.00

170.40±51.38

137.32±37.30

<0.001

 p-tau (pg/ml)

47.59±28.66

25.61±1.44

32.89±2.90

<0.001

 t-tau (pg/ml)

99.32±58.71

86.82±52.21

130.50±62.52

<0.001

p-tau/Aβ₄₂

0.34±0.25

0.30±0.22

0.45±0.28

<0.001

t-tau/Aβ₄₂

0.69±0.53

0.58±0.47

0.96±0.56

<0.001

CSVD markers

 PV-WMH, median (Q1, Q3)

1 (1,2)

1 (1,2)

2 (1,2)

0.012

 DM-WMH, median (Q1, Q3)

1 (0,1)

1 (0,1)

1 (0,2)

0.016

 WMH volume

7.22±8.98

6.77±8.85

8.33±9.22

0.096

 BG-PVS, median (Q1, Q3)

3 (3,3)

3 (3,3)

3 (3,3)

0.780

 CS-PVS, median (Q1, Q3)

3 (3,4)

3 (3,4)

3 (3,4)

0.116

 Microbleeds, n. (%)

78 (17.5)

46 (14.6)

32 (24.8)

0.009

 Lacunes, n. (%)

85 (19.1)

50 (15.8)

35 (27.1)

0.006

NPI

 Hyperactivity

1.79±3.49

1.42±2.98

2.69±4.38

<0.001

  Agitation(C)

0.53±1.34

0.42±1.19

0.79±1.63

0.001

  Elation(F)

0.07±0.56

0.07±0.48

0.07±0.71

0.652

  Disinhibition(H)

0.25±0.94

0.19±0.86

0.38±1.10

0.004

  Irritability(I)

0.73±1.69

0.64±1.56

0.95±1.96

0.051

  Motor behavior(J)

0.22±0.93

0.10±0.58

0.50±1.43

<0.001

  Psychosis

0.99±2.28

0.98±2.23

1.01±2.41

0.832

Delusion(A)

0.12±0.77

0.05±0.43

0.30±1.24

0.002

  Hallucinations(B)

0.04±0.33

0.03±0.30

0.07±0.38

0.037

  Night-time(K) behavior(K)

0.82±2.23

0.90±2.18

0.64±1.59

0.336

  Affective symptoms

1.09±2.00

1.00±2.05

1.30±1.86

0.020

  Anxiety(E)

0.49±1.34

0.43±1.36

0.61±1.28

0.012

  Depression(D)

0.60±1.18

0.57±1.19

0.68±1.15

0.221

  Apathy

1.31±2.90

0.83±2.17

2.48±3.96

<0.001

  Apathy(G)

0.77±1.83

0.52±1.54

1.36±2.29

<0.001

  Appetite(L)

0.54±1.75

0.31±1.28

1.12±2.47

<0.001

  Total

5.17±7.38

4.23±6.52

7.47±8.75

<0.001