Table 1 Overview of modules integrated in the digital tool: 1. cCOG, 2. cMRI, 3. cDSI, 4. Patient report
From: Use of a digital tool to support the diagnostic process in memory clinics–a usability study
Module 1. Web-based cognitive testing, cCOG cCOG is a web-based cognitive test tool that was validated in CN, MCI, and patients with dementia [11]. cCOG has a completion time of approximately 20 minutes and consists of 6 subtasks (memory learning and recall, modified trail making test A/B, reaction time task, fragmented letter test) and 7 questions relating DLB’s core features [19]. cCOG can be performed at home or in the clinic and is currently available in Dutch, English, Danish, Finnish, Swedish, and Italian. |
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Module 2. Quantification of MRI images, cMRI cMRI extracts imaging markers from MRI scans using automatic quantification methods [20]. From T1 images, volumes of 133 brain regions and various disease-specific imaging biomarkers, such as computed medial temporal lobe (cMTA) score, computed global cortical atrophy (cGCA) score and anterior posterior score, are calculated. From FLAIR, white-matter hyperintensity volumes and computed Fazekas are quantified. MRI images acquired on either 1.5T or 3T scanners can be used [12]. cMRI is able to accurately aid in the differential diagnosis of the four main diseases causing dementia (AD, DLB, VaD, and FTD) [12, 20] |
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Module 3. Clinical decision support tool based on machine learning, cDSI Clinical decision support tool based on machine learning (cDSI). The DSI is a data-driven classifier that provides a scalar index between zero and one, indicating a patient’s disease, being CN, AD dementia, VaD, DLB, or FTD [21, 22]. cDSI considers all available patient data, including demographic information (age, sex, education), neuropsychological test results, cCOG results, cMRI quantification, and CSF results (amyloid-beta, t-tau, p-tau). The DSI has been extensively studied and was validated in clinical practice [10, 23]. |
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Module 4. Patient report The available patient information is combined into a simple patient report which was co-created in a previous study with patients and care partners [13]. The patient report contains information about the diagnosis, individual test results, practical tips, and where to find more information. Clinicians can add their own text to subsections of the report. In the current study, clinicians had to fill in the final diagnosis themselves. |
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