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Table 1 Baseline demographics

From: Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow

 

Healthy controls

Alzheimer’s disease

p-value

Number of participants

15

25

 

Age, mean (SD)

69.5 (7.93)

70.3 (7.79)

0.723

Males/females

8/7

15/10

0.680

Education, mean (SD)

15.2 (2.04)

14.3 (3.08)

0.219

Cholinesterase inhibitor, n (%)

0

24 (96%)

 

SSRI/SNRI, n (%)

1 (7%)

4 (16%)

 

MMSE, mean (SD)

29.3 (0.88)

23.4 (3.29)

< 0.001

NPI

 

4.83 (4.06)

 

FAQ IADL

 

14.28 (5.78)

 

Time in days between MRI and ear-EEG, mean (SD)*

21.4 (12.46)

17.8 (10.26)

0.332

Left hippocampus volume, % of ICV, mean (SD)

0.26 (0.03)

0.21 (0.03)

< 0.001

Right hippocampus volume, % of ICV, mean (SD)

0.26 (0.3)

0.21 (0.03)

< 0.001

  1. SSRI/SNRI: Selective Serotonin Reuptake Inhibitor/ Serotonin and Noradrenaline Reuptake Inhibitor, MMSE: Mini-Mental State Examination, ADL: Activities of Daily Living, NPI: Neuropsychiatric Inventory, Time in days refers to the number of days between first day of ear-EEG recording and MRI scan in patients who were included in the regression analysis, SD: Standard deviation, ICV: intracranial volume, * Only for the 24 patients with AD with sufficient ear-EEG data