Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer’s disease: a cross-section study using optical coherence tomography angiography

Sun, Yan; Zhang, Lumi; Ye, Hui; Leng, Lumin; Chen, Yi; Su, Yujie; Ren, Peifang; Lu, Hong; Peng, Guoping

doi:10.1186/s13195-024-01431-w

Alzheimer's Research & Therapy

Table 2 Comparison of flow area and vascular density of ICP and SCP in three groups

From: Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer’s disease: a cross-section study using optical coherence tomography angiography

	HC (n = 49)	AD (n = 34)	PCA (n = 18)
Flow area of ICP (mm²)
0–1 mm circle	0.1186 ± 0.0321	0.1197 ± 0.0448	0.1025 ± 0.0221^**
0–3 mm circle	2.2454 ± 0.1589	2.0904 ± 0.2746^**	2.0949 ± 0.2319^*
1–3 mm ring	2.2167 ± 0.1567	1.9707 ± 0.2487^**	1.9923 ± 0.2248
Superior inner	0.5370 ± 0.0417	0.4962 ± 0.0862^*	0.4987 ± 0.0658
Temporal inner	0.5179 ± 0.0481	0.4763 ± 0.0686^**	0.4966 ± 0.0551
Inferior inner	0.5382 ± 0.0454	0.5000 ± 0.0602^**	0.4994 ± 0.0571
Nasal inner	0.5336 ± 0.0417	0.4982 ± 0.0766^*	0.4976 ± 0.0642
Vascular density of ICP (%)
0–1 mm circle	14.3594 ± 4.7597	15.4557 ± 7.3033	12.1258 ± 2.9380^†
0–3 mm circle	32.8780 ± 3.4920	30.1879 ± 5.4381^*	31.2835 ± 3.7517
1–3 mm ring	35.1994 ± 3.7448	32.0346 ± 5.5376^**	33.6852 ± 4.1439
Superior inner	35.4247 ± 4.5063	32.4111 ± 7.6077	32.9766 ± 5.7374
Temporal inner	34.3944 ± 5.1393	31.0571 ± 6.5958^*	34.3877 ± 4.7689
Inferior inner	35.5829 ± 4.8639	31.5183 ± 6.9000^*	33.2461 ± 4.7481
Nasal inner	35.3952 ± 4.1250	33.1594 ± 8.1473	34.1256 ± 5.4461
Flow area of SCP (mm²)
0–1 mm circle	0.0907 ± 0.0330	0.0949 ± 0.0460	0.0771 ± 0.0212^{** †}
0–3 mm circle	2.7850 ± 0.2063	2.6128 ± 0.3225^***	2.6443 ± 0.3781^**
1–3 mm ring	2.6942 ± 0.1964	2.5180 ± 0.3004^***	2.5672 ± 0.3670^*
Superior inner	0.7198 ± 0.0550	0.6674 ± 0.1024^**	0.6794 ± 0.0905^*
Temporal inner	0.6064 ± 0.0483	0.5687 ± 0.0797^**	0.5921 ± 0.0833
Inferior inner	0.7122 ± 0.0611	0.6733 ± 0.0687^**	0.6818 ± 0.1052^*
Nasal inner	0.6559 ± 0.0537	0.6085 ± 0.0897^**	0.6139 ± 0.1032^**
Vascular density of SCP (%)
0–1 mm circle	8.9057 ± 4.2500	8.9495 ± 5.8354	7.2404 ± 2.8073^**
0–3 mm circle	41.6584 ± 3.4751	38.9816 ± 5.1625^**	39.6129 ± 7.1054^*
1–3 mm ring	45.7641 ± 3.7437	42.7460 ± 5.4349^**	43.6711 ± 7.7809^*
Superior inner	49.4141 ± 3.9880	45.7721 ± 7.3140^*	46.7333 ± 7.7789
Temporal inner	40.3776 ± 2.8981	37.8033 ± 6.2844^*	39.5759 ± 7.0591
Inferior inner	48.7654 ± 4.6209	46.0670 ± 5.0531^**	46.9004 ± 8.5887
Nasal inner	44.5076 ± 4.4180	41.3367 ± 6.8787^**	41.4901 ± 6.8445^*

Abbreviations: HC Healthy control, AD Alzheimer’s disease, PCA Posterior cortical atrophy, ICP Intermediate capillary plexus, SCP Superior capillary plexus. Assessment Values are mean ± standard deviation (SD)
^* p < 0.05: AD, PCA vs HC, by post hoc test
^** p < 0.01: AD, PCA vs HC, by post hoc test
^*** p < 0.001: AD, PCA vs HC, by post hoc test
^† p < 0.05: AD vs PCA, by post hoc test

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