Table 1 Demographic of patients included in the study
BioFINDER-1 cohort | ADNI cohort | |||
|---|---|---|---|---|
Non-AD | Early AD | Non-AD | Early AD | |
No. of subjects | 332 | 108 | ||
223 (67.2%) | 109 (32.8%) | 85 (78.7%) | 23 (21.3%) | |
MCI | 92 (41.2%) | 78 (71.6%) | 85 (100%) | 23 (100%) |
Female | 106 (47.5%) | 51 (46.8%) | 27 (31.8%) | 10 (43.5%) |
Age (years) | 70.2 ± 5.5 | 72.1 ± 4.7 | 70.9 ± 7.0 | 74.0 ± 4.9 |
Education (years) | 12.0 ± 3.7 | 11.8 ± 3.5 | 16.1 ± 2.6 | 16.1 ± 2.9 |
Baseline MMSE score | 28.2 ± 1.7 | 27.1 ± 1.7 | 28.3 ± 1.5 | 25.9 ± 2.2 |
APOE ε4 | 0.4 ± 0.6 | 1.0 ± 0.7 | 0.5 ± 0.7 | 0.9 ± 0.7 |
ADAS-cog delayed recall (no of errors) | 4.2 ± 2.4 | 6.7 ± 2.1 | 4.1 ± 2.2 | 6.6 ± 2.4 |
Hippocampal volume (mm3) | 3339 ± 480 | 2927 ± 415 | 3592 ± 447 | 3130 ± 483 |
Intracranial volume (cm3) | 1136 ± 153 | 1114 ± 107 | 1502 ± 134 | 1440 ± 155 |
Aβ-positive | 25% | 100% | 29% | 82% |