Table 2 Characteristics of participants across ANU-ADRI categories

N

1078

110

793

175

—

Age (years), mean (SD)

62.58 (10.06)

57.89 (7.27)

60.19 (8.57)

76.35 (5.25)

 < 0.001^a

Gender, female (%)

476 (44.16%)

20 (18.20)

377 (47.50)

79 (45.10)

 < 0.001^b

Education (years), mean (SD)

9.30 (4.36)

13.42 (2.32)

9.07 (4.19)

7.77 (4.61)

 < 0.001^a

APOE ε4, yes (%)

149 (15.90%)

17 (18.70)

110 (15.90)

22 (14.40)

0.674^b

CM-MMSE, mean (SD)

27.07 (3.18)

28.64 (1.63)

27.19 (3.04)

25.54 (3.86)

 < 0.001^a

MoCA, mean (SD)

22.39 (4.76)

22.37 (4.76)

22.39 (4.75)

22.38 (4.76)

 < 0.001^a

ANU-ADRI score, mean (SD)

4.65 (9.00)

-6.73 (1.46)

2.61 (4.47)

21.04 (6.13)

 < 0.001^a

CSF AD biomarkers

 Aβ42, mean (SD)

345.48 (214.07)

343.43 (198.54)

345.79 (219.15)

345.39 (201.06)

0.994^a

 P-TAU181, mean (SD)

44.25 (13.67)

41.13 (13.01)

43.58 (13.09)

49.43 (15.44)

< 0.001^a

 T-TAU, mean (SD)

197.41 (84.98)

173.61 (75.71)

191.19 (79.41)

241.79 (100.07)

< 0.001^a

 P-TAU181/Aβ42, mean (SD)

0.18 (0.13)

0.16 (0.11)

0.18 (0.13)

0.20 (0.15)

0.043^a

 T-TAU/Aβ42, mean (SD)

0.80 (0.64)

0.71 (0.61)

0.78 (0.61)

0.98 (0.78)

 < 0.001^a

Central inflammatory markers

 sTREM2

17,886.95 (7002.11)

17,386.67 (6135.75)

17,402.75 (6922.29)

20,421.25 (7391.03)

 < 0.001^a