Fig. 3
From: ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
CSF p-tau and t-tau mediated association between ANU-ADRI scores and cognition. Models of mediation for ANU-ADRI scores, cognition (MMSE and MoCA), and CSF biomarkers (p-tau and t-tau), with ANU-ADRI scores as independent variable and CSF biomarkers as mediator and cognition as dependent variable. Each model path was adjusted for APOE ε4 status. a is the effect of the independent variable on mediators; b is the effect of mediators on dependent variables after controlling the influence of independent variables; c is the total effect of independent variables on dependent variables; c’ is the direct effect; IE is the indirect effect. ANU-ADRI, Australian National University Alzheimer Disease Risk Index; CSF, cerebrospinal fluid; P-tau, phosphorylated tau; T-tau, total tau; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment