Table 2 Heterogeneity and pleiotropy test between blood phytosterols levels, Alzheimer's disease, and Parkinson's disease
Exposure | Outcome | IVs (N) | Cochran Q test | MR-Egger Intercept (P) | MR-PRESSO RSSobs (P)a | |
|---|---|---|---|---|---|---|
MR-Egger (P) | IVW (P) | |||||
Stigmasterol | AD (IGAP) | 3 | 1.697 (0.193) | 1.720 (0.423) | 0.0040 (0.925) | - |
AD (IGAP + UKB) | 3 | 0.145 (0.703) | 0.192 (0.909) | 0.0037 (0.865) | - | |
PD (IPDGC) | 4 | 0.654 (0.721) | 0.661 (0.882) | 0.0027 (0.944) | 1.259 (0.873) | |
PD AAO (IPDGC) | 4 | 1.839 (0.399) | 1.846 (0.605) | -0.0188 (0.940) | 3.157 (0.645) | |
Sitosterol | AD (IGAP) | 6 | 9.235 (0.055) | 9.568 (0.088) | -0.0087 (0.723) | 13.369 (0.239) |
AD (IGAP + UKB) | 6 | 0.472 (0.976) | 1.406 (0.924) | -0.0096 (0.388) | 2.843 (0.888) | |
PD (IPDGC) | 6 | 3.346 (0.502) | 3.432 (0.634) | 0.0054 (0.783) | 3.763 (0.778) | |
PD AAO (IPDGC) | 6 | 2.015 (0.733) | 2.029 (0.845) | -0.0151 (0.909) | 2.507 (0.897) | |
Campesterol | AD (IGAP) | 3 | 0.007 (0.932) | 0.393 (0.821) | -0.0122 (0.646) | - |
AD (IGAP + UKB) | 3 | 0.110 (0.740) | 0.506 (0.777) | -0.0082 (0.643) | - | |
PD (IPDGC) | 3 | 0.465 (0.495) | 0.618 (0.734) | -0.0099 (0.763) | - | |
PD AAO (IPDGC) | 3 | 2.129 (0.144) | 2.136 (0.344) | -0.0139 (0.964) | - | |
Brassicasterol | AD (IGAP) | 4 | 4.612 (0.100) | 5.412 (0.144) | 0.0153 (0.615) | 15.931 (0.302) |
AD (IGAP + UKB) | 4 | 0.553 (0.758) | 3.061 (0.382) | 0.0179 (0.254) | 9.708 (0.435) | |
PD (IPDGC) | 4 | 1.244 (0.537) | 1.408 (0.704) | 0.0089 (0.725) | 1.711 (0.832) | |
PD AAO (IPDGC) | 4 | 0.856 (0.652) | 1.837 (0.607) | -0.1438 (0.426) | 2.417 (0.704) | |