Fig. 6
From: Amyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
Aβo-incubated pericytes demonstrated a proinflammatory profile and decreased tight-junction proteins in endothelial cells in vitro. A-B Western blotting analysis of PDGFRβ protein expression level in primary cultured pericytes incubated with Aβo for 24 h and 72 h. C Heat map summary of Aβo-stimulated genes in primary pericytes incubated with Aβo for 24 h and 72 h. D Schematic diagram of bEnd3 cells incubated with primary pericytes supernatant. E–F Western blotting analysis of tight junction protein (ZO-1, Claudin-5, and Occludin) expression levels in bEnd3 cells incubated with Aβo and primary pericytes supernatant. All the data were presented as mean ± SEM. * p < 0.05, ** p < 0.01