Fig. 4
From: Amyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
The level of NG2 expression decreased after Aβo injection in NG2-DsRed mice. A Representative images of coronal brain section of the vehicle (2%DMSO) and Aβo-injected NG2-DsRed mice. The area 1 mm around the injection point (the arrow points) was defined as the injection region and the ipsilateral cortex area 1-4 mm away from the injection point was defined as the para-injection region. Scale bar: 250 μm B Representative immunofluorescent staining images of NG2 (red) and lectin (grey) in the injection region of both groups. Scale bar: 50 μm C Quantification of NG2-positive coverage length (upper panel) and area (low panel) in the injection region of both groups. D Representative immunofluorescent staining images of NG2 (red) and lectin (grey) in the para-injection region of both groups. Scale bar: 50 μm E Quantification of NG2-positive coverage length (upper panel) and area (low panel) in the para-injection region of both groups. All the data were presented as mean ± SEM and analyzed using an unpaired t-test. n = 6 for each group. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001