Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers

Table 2 Correlation analysis between white matter hyperintensity (WMH) and peripheral vascular/inflammation markers and clinical parameters in bvFTD

WMH	Others	R	p	FDR adjusted p
Frontal	IL-6	0.4472	0.0103	0.0948
	TNFa	0.5156	0.0025	0.0381^*
	MMSE	− 0.3598	0.0431	0.2378
	TMT-B	0.3867	0.0288	0.1925
	IADL	0.4938	0.0041	0.0509
	ADL	0.4740	0.0061	0.0450^*
	CDR® plus NACC FTLD-SB	0.3975	0.0243	0.1698
	BEHAV	0.4999	0.0036	0.0484^*
Sub-lobar	Pentraxim	0.4138	0.0162	0.0521
Sub-lobar	TMTB	0.4848	0.0049	0.0556
Limbic	IL-6	0.3719	0.0361	0.2144
	TNFa	0.5520	0.0011	0.0190^*
	TMTB	0.4914	0.0043	0.0520
	IADL	0.3935	0.0259	0.1842
	ADL	0.3758	0.0341	0.1328
	CDR® plus NACC FTLD-SB	0.3781	0.0328	0.2081
	BEHAV	0.3828	0.0306	0.2022

Adjusted for age, sex, and years of education
Abbreviations: bvFTD behavioral variant frontotemporal dementia, MMSE Mini-Mental State Examination, CDR® plus NACC FTLD-SB the sum of the six domain scores of the CDR plus the behavior/comportment/personality and language domains, BEHAV behavior/comportment/personality, LANG language, TMT Trail Making Test, ADL activities of daily living scale
* of significance

ISSN: 1758-9193