Table 1 Baseline characteristics of cohort population by presence of dementia

Follow-up period (years)

10.85 ± 2.79

11.12 ± 2.57

7.26 ± 3.10

-

Age (years)

58.8 ± 10.8

57.8 ± 10.2

73.0 ± 8.5

< 0.0001

< 65

537,743 (71.5%)

530,107 (75.7%)

7,636 (14.6%)

< 0.0001

≥ 65

214,462 (28.5%)

169,719 (24.3%)

44,743 (85.4%)

Sex

Male

348,125 (46.3%)

332,169 (47.5%)

15,956 (30.5%)

< 0.0001

Female

404,080 (53.7%)

367,657 (52.5%)

36,423 (69.5%)

HSV infection

None

589,529 (78.4%)

544,963 (77.9%)

44,566 (85.1%)

< 0.0001

Total

162,676 (21.6%)

154,863 (22.1%)

7,813 (14.9%)

Eye

17,659 (2.3%)

16,627 (2.4%)

1,032 (2%)

CNS

64 (0%)

60 (0%)

4 (0%)

Complicated

11,310 (1.5%)

10,903 (1.6%)

407 (0.8%)

Simple

133,643 (17.8%)

127,273 (18.2%)

6,370 (12.2%)

VZV infection

None

567,874 (75.5%)

526,176 (75.2%)

41,698 (79.6%)

< 0.0001

Total

184,331 (24.5%)

173,650 (24.8%)

10,681 (20.4%)

Eye

4,687 (0.6%)

4,388 (0.6%)

299 (0.6%)

CNS

45,515 (6.1%)

42,568 (6.1%)

2,947 (5.6%)

Complicated

35,503 (4.7%)

33,421 (4.8%)

2,082 (4%)

Simple

98,626 (13.1%)

93,273 (13.3%)

5,353 (10.2%)

HSV or VZV infection

No

475,884 (63.3%)

438,832 (62.7%)

37,052 (70.7%)

< 0.0001

HSV only

91,990 (12.2%)

87,344 (12.5%)

4,646 (8.9%)

VZV only

113,645 (15.1%)

106,131 (15.2%)

7,514 (14.3%)

Co-infection

70,686 (9.4%)

67,519 (9.6%)

3,167 (6%)

Depression

58,961 (7.8%)

51,704 (7.4%)

7,257 (13.9%)

< 0.0001

Dyslipidaemia

137,800 (18.3%)

124,673 (17.8%)

13,127 (25.1%)

< 0.0001

Ischaemic stroke

30,950 (4.1%)

25,086 (3.6%)

5,864 (11.2%)

< 0.0001

Coronary heart disease

86,082 (11.4%)

75,653 (10.8%)

10,429 (19.9%)

< 0.0001

Hypertension

239,976 (31.9%)

210,783 (30.1%)

29,193 (55.7%)

< 0.0001

Diabetes mellitus

157,642 (21%)

139,387 (19.9%)

18,255 (34.9%)

< 0.0001

Chronic kidney disease

3,287 (0.4%)

2,913 (0.4%)

374 (0.7%)

< 0.0001

Body mass index

Underweight

15,993 (2.1%)

13,916 (2%)

2,077 (4%)

< 0.0001

Normal

220,444 (29.3%)

206,375 (29.5%)

14,069 (26.9%)

Overweight

169,660 (22.6%)

160,748 (23%)

8,912 (17%)

Obese

226,268 (30.1%)

214,846 (30.7%)

11,422 (21.8%)

not applicable

119,840 (15.9%)

103,941 (14.9%)

15,899 (30.4%)

Household income level

Low

138,623 (18.4%)

129,529 (18.5%)

9,094 (17.4%)

< 0.0001

Lower middle

136,824 (18.2%)

128,962 (18.4%)

7,862 (15%)

Higher middle

181,648 (24.1%)

170,718 (24.4%)

10,930 (20.9%)

High

255,307 (33.9%)

237,910 (34%)

17,397 (33.2%)

not applicable

39,803 (5.3%)

32,707 (4.7%)

7,096 (13.5%)