Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities

Table 3 Effect of moderator on association between baseline Aβ deposition and ΔWMH volume

	Δ WMH volume ^a
	β (95% CI)	p
Age × Baseline Aβ	-0.012 (-0.029–0.005)	0.173
Sex × Baseline Aβ	-0.350 (-0.621 – -0.079)	0.011
APOE ε4 positivity × Baseline Aβ	-0.058 (-0.369–0.253)	0.714
Vascular risk score × Baseline Aβ	-0.039 (-0.185–0.106)	0.595
CDR sum of box × Baseline Aβ	0.013 (-0.068–0.095)	0.748
Baseline WMH × Baseline Aβ	-0.083 (-0.566–0.400)	0.736

Note
^a Adjusting for age, sex, APOE ε4 positivity, Vascular risk score, CDR sum of box, baseline WMH
Abbreviations: APOE ε4 = Apolipoprotein ε4, CDR = Clinical dementia rating, SUVR = Standardized uptake value ratio, Aβ = Beta-amyloid, WMH = White matter hyperintensity

ISSN: 1758-9193