Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities

Table 2 Associations between Aβ or Tau deposition and WMH volume

Independent variable	Δ WMH volume ^a		Δ Aβ ^b		Δ Tau ^c
Independent variable	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
baseline Aβ, SUVR	0.238 (0.059–0.418)	0.009	-	-	-	-
baseline Tau, SUVR	-0.232 (-0.532–0.068)	0.128	-	-	-	-
baseline WMH volume	-	-	0.008 (-0.016–0.032)	0.502	0.054 (-0.106–0.214)	0.503

Note
^a Adjusting for age, sex, APOE ε4 positivity, Vascular risk score, CDR sum of box, baseline WMH
^b Adjusting for age, sex, APOE ε4 positivity, Vascular risk score, CDR sum of box, baseline Aβ
^c Adjusting for age, sex, APOE ε4 positivity, Vascular risk score, CDR sum of box, baseline Tau
Abbreviations: Aβ = Beta-amyloid, SUVR = Standardized uptake value ratio, WMH = White matter hyperintensity

ISSN: 1758-9193