Table 1 Participant characteristics
| Â | Longitudinal analysis | ||||
|---|---|---|---|---|---|
Aβ - ΔWMH (n = 282) | WMH - ΔAβ (n = 282) | Tau - ΔWMH (n = 117) | WMH - ΔTau (n = 66) | ||
No. (% of sample) | Â | Â | Â | Â | |
| Â | Female, n (%) | 161 (57.09) | 161 (57.09) | 75 (64.10) | 43 (65.15) |
|  | APOE ε4 carrier, n (%) | 75 (26.60) | 75 (26.60) | 38 (32.48) | 20 (30.30) |
| Â | Diagnosis (CN / MCI / AD) | 169 / 80 / 33 | 169 / 80 / 33 | 53 / 32 / 32 | 37 / 15 / 14 |
Mean (standard deviation) | Â | Â | Â | Â | |
| Â | Age, y | 70.9 (7.90) | 70.9 (7.90) | 73.7 (7.88) | 74.0 (6.97) |
| Â | Education, y | 11.1 (4.99) | 11.1 (4.99) | 10.9 (4.91) | 10.6 (4.95) |
| Â | MMSE score | 24.6 (4.21) | 24.6 (4.21) | 23.4 (5.64) | 24.1 (5.02) |
| Â | Vascular risk score | 2.19 (1.02) | 2.19 (1.02) | 2.34 (1.04) | 2.33 (1.04) |
| Â | CDR sum of box | 0.94 (1.52) | 0.94 (1.52) | 2.00 (2.72) | 1.59 (2.43) |
|  | Aβ-PET SUVR | 0.874 (0.236) | 0.874 (0.236) | 0.941 (0.287) | 0.914 (0.273) |
|  | ΔAβ-PET SUVR | 0.005 (0.065) | 0.005 (0.065) | 0.021 (0.108) | 0.021 (0.107) |
| Â | Tau-PET SUVR | - | - | 1.12 (0.262) | 1.12 (0.215) |
|  | Δ Tau-PET SUVR | - | - | - | 0.029 (0.227) |
| Â | WMHs (log-transformed) | 0.995 (0.335) | 0.995 (0.335) | 1.06 (0.37) | 1.04 (0.387) |
|  | Δ WMHs (log-transformed) | 0.032 (0.30) | 0.032 (0.30) | 0.054 (0.381) | 0.006 (0.271) |