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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation, positive biomarkers and developing AD-like pathology

Fig. 5

Histological staining of microglia and astrocytes in the brain of T2DM monkeys. A Representative image of monkey brains immunostaining for microglial cells. High-magnification images are shown on the right. B Representative image of monkey brains immunostaining for astrocyte cells. High-magnification images are shown on the right. C Merge image of Aβ plaques (6E10) immunofluorescence staining (green) and TNF-α (yellow) in the T2DM monkeys. D Merge image of Aβ plaques (6E10) immunofluorescence staining (green) and TNF-α (yellow) in the NC group. E Number of activated microglia in the T2DM group and NC group. F Number of activated astrocytes in the T2DM group and NC group. G Quantification of mean intensity of 6E10 in the T2DM group and NC group. H Quantification of mean intensity of TNF-α in the T2DM group and NC group. Results presented as mean ± SD. Unpaired t-test were applied (n = 9/T2DM group; n = 3/NC group) (p > 0.05 = ns; p ≤ 0.05 = *; p ≤ 0.01 = **; p ≤ 0.001 = ***). Scale bars represent 50 μm

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Alzheimer's Research & Therapy

ISSN: 1758-9193