Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Kikuchi, Masataka; Miyashita, Akinori; Hara, Norikazu; Kasuga, Kensaku; Saito, Yuko; Murayama, Shigeo; Kakita, Akiyoshi; Akatsu, Hiroyasu; Ozaki, Kouichi; Niida, Shumpei; Kuwano, Ryozo; Iwatsubo, Takeshi; Nakaya, Akihiro; Ikeuchi, Takeshi

doi:10.1186/s13195-024-01414-x

Alzheimer's Research & Therapy

Table 5 Polygenic risk of conversion of MCI to AD

From: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

5a PRS.noAPOE
	All MCI subjects			MCI subjects without APOE ε4			MCI subjects with APOE ε4
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
PRS (High group)	1.301	0.847–1.998	0.230	2.216	1.058–4.643	0.035	0.985	0.770–1.259	0.902
Age	1.070	0.846–1.353	0.574	1.069	0.725–1.578	0.736	0.961	0.687–1.344	0.816
Sex (Male)	0.858	0.532–1.383	0.529	0.589	0.257–1.353	0.212	0.983	0.539–1.793	0.956
Education year	0.791	0.605–1.035	0.087	0.745	0.452–1.229	0.249	0.856	0.610–1.202	0.37
PC1	0.939	0.769–1.146	0.534	0.769	0.541–1.093	0.143	1.034	0.795–1.343	0.806
PC2	0.954	0.753–1.209	0.697	1.028	0.713–1.481	0.884	0.900	0.647–1.251	0.529
APOE ε4 alleles	1.604	1.153–2.230	0.005	NA	NA	NA	1.108	0.516–2.382	0.793
APOE ε2 alleles	1.447	0.440–4.755	0.543	1.665	0.492–5.635	0.412	NA	NA	NA
Log-rank test (high vs low PRS)			0.202			0.031			0.292
5b PRS.adjLD
	All MCI subjects			MCI subjects without APOE ε4			MCI subjects with APOE ε4
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
PRS (High group)	1.161	0.752–1.792	0.500	1.547	0.727–3.296	0.258	1.030	0.812–1.305	0.809
Age	1.137	0.902–1.433	0.278	1.251	0.819–1.912	0.301	1.011	0.742–1.379	0.943
Sex (Male)	0.736	0.445–1.219	0.234	0.571	0.234–1.394	0.219	0.808	0.425–1.538	0.516
Education year	0.927	0.714–1.205	0.573	0.873	0.531–1.435	0.592	0.962	0.689–1.344	0.821
PC1	0.909	0.738–1.119	0.368	0.682	0.460–1.011	0.057	1.042	0.801–1.355	0.758
PC2	0.927	0.733–1.173	0.529	1.006	0.697–1.452	0.975	0.910	0.663–1.249	0.558
APOE ε4 alleles	1.560	1.102–2.209	0.012	NA	NA	NA	1.201	0.543–2.658	0.651
APOE ε2 alleles	0.708	0.169–2.965	0.636	0.709	0.163–3.085	0.647	NA	NA	NA
Log-rank test (high vs low PRS)			0.236			0.174			0.650

Abbreviations: HR Hazard ratio, 95% CI 95% confidence interval, APOE apolipoprotein E
Cox proportional hazard model: Conversion/follow-up = PRS (Low = 0, High = 1) + Age + Sex (Female = 0, Male = 1) + Education year + PC1 + PC2 + APOE ε4 alleles + APOE ε2 alleles
HR, 95% CI, and p-value were calculated by a Cox proportional hazard model controlling age at examination, sex, education years, the first two PCs, and the doses of APOE ε4 and ε2 alleles. Statistically significant was highlighted in bold

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com