Table 3 Predictive accuracy of each model

PRS and APOE alleles

 APOE ε4

0.693

0.638–0.747

0.691

0.654–0.730

0.701

0.665–0.735

 APOE ε4 + ε2

0.696

0.640–0.751

0.698

0.659–0.737

0.712

0.675–0.750

 PRS.noAPOE

0.640

0.576–0.704

0.550

0.500–0.599

0.602

0.559–0.649

 PRS.adjLD

0.639

0.574–0.704

0.541

0.493–0.589

0.594

0.552–0.640

 PRS.incAPOE

0.706

0.643–0.764

0.628

0.590–0.625

0.679

0.639–0.720

 PRS.noAPOE + APOE ε4 + ε2

0.755

0.695–0.807

0.731

0.686–0.773

0.730

0.692–0.767

 PRS.adjLD + APOE ε4 + ε2

0.748

0.687–0.800

0.728

0.680–0.771

0.731

0.693–0.769

PRS and all covariates

 Age + Sex + (Education) + APOE ε4

0.837

0.788–0.883

0.725

0.681–0.770

0.710

0.670–0.750

 Age + Sex + (Education) + APOE ε4 + ε2

0.838

0.789–0.883

0.723

0.679–0.768

0.706

0.665–0.746

 Age + Sex + (Education) + APOE ε4 + ε2 + PRS.noAPOE

0.855

0.808–0.898

0.737

0.693–0.780

0.722

0.683–0.761

 Age + Sex + (Education) + APOE ε4 + ε2 + PRS.adjLD

0.853

0.806–0.897

0.733

0.690–0.777

0.718

0.678–0.757