Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Table 1 Summary of the J-ADNI participants

	CU	MCI	ADD	p value
N	145	220	139	-
Age in years, mean ± SE	67.8 ± 0.472	72.8 ± 0.397	73.8 ± 0.563	< 2.00 × 10^−16a
Sex (M:F)	72:73	106:114	59:80	0.429^b
Years of education, mean ± SE	13.8 ± 0.230	13.0 ± 0.189	12.5 ± 0.266	8.69 × 10^{−4 a}
APOEε4 alleles (0:1:2)	109:34:2	106:97:17	55:62:22	2.31 × 10^{−10 c}
APOEε2 alleles (0:1:2)	134:11:0	211:9:0	133:6:0	0.323 ^c

Abbreviations: CU Cognitively unimpaired, MCI Mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE Apolipoprotein E, SE Standard error, ANOVA analysis of variance
^aOne-way ANOVA
^bChi-squared test
^cFisher’s exact test

ISSN: 1758-9193