Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease

Table 2 Median treatment effects estimated by the PMRM, MMRM, and the Cox proportional hazards model^a

Sample size	Study length (months)	Median effect
Sample size	Study length (months)	PMRM (% time delay, measured on the horizontal axis)	MMRM (% reduction in CDR-SB, measured on the vertical axis)	Cox (HR of progressing to dementia)
200	18	19%	23%	0.84
200	24	20%	26%	0.82
200	36	20%	25%	0.82
300	18	19%	23%	0.85
300	24	19%	26%	0.83
300	36	20%	25%	0.84
400	18	19%	22%	0.85
400	24	20%	26%	0.83
400	36	20%	25%	0.83
500	18	19%	22%	0.85
500	24	20%	26%	0.83
500	36	20%	25%	0.83
600	18	19%	22%	0.85
600	24	19%	26%	0.83
600	36	20%	25%	0.83
700	18	19%	22%	0.85
700	24	19%	25%	0.83
700	36	20%	25%	0.83

^aData are shown across scenarios with different sample sizes and study lengths (1000 simulations per scenario). The table shows the treatment effect at the final visit for the PMRM and the MMRM. The hazard ratio summarizes the treatment effect over the entire study duration

ISSN: 1758-9193