Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease

Table 1 Baseline characteristics for 537 participants included from ADNI^a

N	Mean age, years	Male, n	Median CDR-SB	Median MMSE
537	72.7	313	1.5	28

^aThis cohort was used to simulate a placebo arm of a clinical trial in amyloid-positive MCI patients. The CDR scale is a staging tool used to determine the severity of dementia-related symptoms across six domains (three cognition domains: memory, orientation, judgment & problem solving; three functional domains: community affairs, home & hobbies, and personal care) each of which is scored between 0 and 3 following a semi-structured interview. The CDR-SB score is the sum of all six domain scores (range 0–18) and is considered a more sensitive measure of dementia severity compared to the alternative CDR-Global score [44]

ISSN: 1758-9193