Fig. 2

Estimated mean trajectory of the change from baseline in CDR-SB in a representative simulated scenario. Trajectories are shown for the PMRM and the MMRM models in a single simulated scenario with 700 subjects and a 36-month trial duration. The estimated trajectories for the PMRM and the MMRM were visually indistinguishable and are shown as a single trajectory within each treatment group (results may therefore deviate slightly from the medians shown in Table 2). The estimated hazard ratio from the Cox proportional model is shown in the bottom-left corner. The delay in disease progression, as estimated by the PMRM, is illustrated by the horizontal dotted lines, and the difference in CDR-SB, as estimated by the MMRM, is represented by the vertical arrows