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Table 2 Summary of survival analysis of 24-h rhythms and developing Alzheimer’s and Parkinson’s disease

From: Impaired 24-h activity patterns are associated with an increased risk of Alzheimer’s disease, Parkinson’s disease, and cognitive decline

 

Alzheimer’s disease (n =187)

Parkinson’s disease (n = 265)

 

HR

95% CI

p-value

HR

95% CI

p-value

Intradaily variability (IV)

1.03

0.88–1.21

0.69

1.10

0.97–1.25

0.12

Interdaily stability (IS)

1.25

1.05–1.48

0.01

0.95

0.83–1.09

0.44

Least active 5 h (L5)

0.69

0.24–1.94

0.48

0.24

0.08–0.69

0.01

Most active 10 h (M10)

0.75

0.61–0.94

0.01

0.20

0.16–0.25

< 0.001

Amplitude

0.79

0.65–0.96

0.02

0.28

0.23–0.34

< 0.001

Mesor

0.78

0.59–0.998

0.048

0.13

0.1–0.16

< 0.001

  1. HR hazard ratio: CI, confidence interval.
  2. All Cox proportional hazards regression models controlled for age at actigraphy collection, sex, college education, baseline general health, baseline body mass index, and baseline Townsend deprivation index. See Fig. 2 for visualization of these data