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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: The role of perfusion, grey matter volume and behavioural phenotypes in the data-driven classification of cognitive syndromes

Fig. 2

Glmnet analyses revealed a combination of regional grey matter volume, perfusion and behavioural scores as discriminative between cognitive syndromes. A Higher temporal, frontal and parietal grey matter volume and higher frontal perfusion were protective against worsening cognitive syndrome. Higher scores on the PSQI (worse sleep quality) and MBI-C Interest (worse behaviour) were associated with increased risk of more advanced cognitive syndromes. B Brain grey matter regions where increased grey matter volume and perfusion were protective against worsening cognitive syndrome. C Differences in glmnet model scores revealed significant differences between groups in a step-wise manner. Abbreviations: MBI-C, mild behaviour impairment checkline; PSQI, Pittsburgh sleep quality index; rHIP, right hippocampus; lSMG, left supramarginal gyrus; lMCC, left mid cingulate cortex; rIFGorb, right inferior fronto-orbital gyrus; lHIP, left hippocampus

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Alzheimer's Research & Therapy

ISSN: 1758-9193