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Table 3 Predictive value of the CSF biomarkers for bvFTD versus PPD and AD

From: The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer’s disease

Biomarker

bvFTD vs PPD

bvFTD vs AD

 

OR (95% CI)

OR (95% CI)

NfL

1.006 (1.003, 1.009)***

1.002 (1.001, 1.003)***

SNAP25

0.999 (0.986, 1.013)

0.966 (0.943, 0.990)**

Ng

1.000 (0.998, 1.001)

0.998 (0.997, 0.999)**

NPTX2

0.997 (0.996, 0.999)**

0.999 (0.997, 1.000)

GluR4

1.000 (0.999, 1.000)

1.000 (0.999, 1.000)

  1. The logistic regression models for each biomarker are controlled for confounders’ age, sex, and psychotropic medication use. OR, odds ratio; NfL, neurofilament light; SNAP25, synaptosomal-associated protein 25; Ng, neurogranin; NPTX2, neuronal pentraxin 2; GluR4, glutamate receptor 4; bvFTD, behavioral frontotemporal dementia; PPD, primary psychiatric disorders; AD, Alzheimer’s disease. *p < 0.05, **p < 0.01, ***p < 0.001
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Alzheimer's Research & Therapy

ISSN: 1758-9193