Table 2 Demographic characteristics of the study cohort

Age

64 (8)^b,d

56 (9)^a,c

66 (7) ^b,d

57 (8) ^a,c

< 0.001

Female sex (%)

21 (37%)

27 (38%)

27 (45%)

13 (33%)

0.737

Psychotropic medication use (% Yes)

16 (30%)

36 (51%)^d

21 (35%)

5 (15%)^b

0.014

CSF biomarkers (pg/mL)

 NfL

1630 (1052)^b,c,d

369 (178)^a,c

848 (332)^a,b,d

337 (187)^a,c

< 0.001

 SNAP25

37 (32)^c

33 (22)^c

51 (19)^a,b,d

28 (7)^c

< 0.001

 Ng

389 (312)^c

351 (230)^c

723 (1069)^a,b,d

283 (107)^c

< 0.001

 NPTX2

401 (270)^b,d

583 (300)^a

477 (227)^b

542 (240)^a

< 0.001

 GluR4

1100 (995)

1223 (1070)

1112 (510)

1070 (386)

0.456

Cognitive domains

 Memory

− 0.13 (0.6)^b,c,d

0.41 (0.6)^a,c

− 0.95 (0.7)^a,b,d

0.73 (0.6)^a,c

< 0.001

 Attention

− 0.35 (1.0)^b,d

0.14 (0.8)^a,c,d

− 0.27 (0.8)^b,d

0.53 (0.3)^a,b,c

< 0.001

 Executive functioning

− 0.44 (0.9)^b,d

0.16 (0.6)^a,c,d

− 0.43 (0.8)^b,d

0.64 (0.4)^a,b,c

< 0.001

 Language

− 0.29 (0.7)^b,d

0.32 (0.5)^a,c

− 0.44 (0.9)^b,d

0.60 (0.5)^a,c

< 0.001

 Visuospatial functioning

0.11 (0.5)^c

0.19 (0.5)^c

− 0.64 (1.1)^a,b,d

0.34 (0.3)^c

< 0.001

 Total cognitive score

− 0.43 (0.8)^b,d

0.2 (0.7)^a,c,d

− 0.60 (0.7)^b,d

0.60 (0.3)^a,b,c

< 0.001

Other tests

 MMSE

24.3 (5)^b,d

26.9 (2)^a,c

20.7 (5)^b,d

28.3 (1)^a,c

< 0.001

 Geriatric depression scale

3.2 (3)^b

6.3 (4)^a,c,d

2.9 (3)^b

3.4 (3)^b

< 0.001

 Ekman 60 faces test

33.7 (7)^b

42.7 (7)^a

-

-

0.023

 FTLD- CDR

7 (4)

-

-

-

-