Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort

Table 5 Multiple linear regression analysis of the association of macular VD and WMH volume including adjusting factors

Variables	Coefficient	t	Significance	Beta
Age	0.05	4.83	< 0.001*	0.37
Sex	0.06	0.41	0.685	0.03
Syndromic diagnosis	0.20	1.40	0.163	0.10
Hypertension	0.34	2.28	0.024	0.16
Diabetes mellitus	0.60	2.09	0.038	0.14
Dyslipidemia	− 0.06	0.44	0.660	− 0.03
Heart disease	0.09	0.38	0.702	0.03
Respiratory disease	0.38	1.75	0.082	0.12
Smoking	− 0.03	0.20	0.845	− 0.01
VD nasal	− 0.04	1.97	0.051	− 0.17
VD temporal	0.05	1.93	0.056	0.19
VD superior	− 0.01	0.58	0.563	− 0.05
VD inferior	0.01	0.47	0.640	0.03

Including age, sex, syndromic diagnosis, hypertension, diabetes mellitus, dyslipidemia, heart disease, respiratory disease, and smoking as adjusting factors
A log transformation was applied to WMH volume measures
Abbreviations: VD Vessel density, WMH White matter hyperintensities
^*Significance was set up at p < 0.0125

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