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Table 2 Crude incidences (95% CI) of overall dementia disaggregated by sex, age, and exposure groups

From: Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data

Sex

Age

Whole population

Exposure groups* (risk at baseline) n (%); mean [sd]

   

Low CVR

Low-intermediate CVR

High-intermediate CVR

High CVR

Previous vascular disease

Women

50,55

0.39 (0.36–0.43)

0.37 (0.34–0.40)

0.62 (0.44–0.88)

1.17 (0.68–2.01)

1.70 (0.81–3.56)

0.96 (0.60–1.54)

 

55,60

1.08 (1.03–1.14)

1.00 (0.94–1.05)

1.44 (1.24–1.67)

1.79 (1.38–2.33)

2.33 (1.66–3.26)

2.28 (1.81–2.89)

 

60,65

3.16 (3.07–3.24)

2.93 (2.84–3.02)

3.62 (3.35–3.92)

4.15 (3.62–4.75)

4.90 (4.14–5.80)

5.33 (4.74–5.99)

 

65,70

7.22 (7.07–7.37)

6.87 (6.71–7.03)

7.77 (7.32–8.23)

8.86 (8.03–9.78)

8.28 (7.19–9.54)

9.88 (9.14–10.68)

 

70,75

14.51 (14.29–14.73)

14.10 (13.87–14.34)

14.79 (14.06—15.55)

15.06 (13.68–16.59)

16.27 (14.10–18.77)

18.15 (17.29–19.06)

 

All

4.79 (4.74–4.84)

4.37 (4.32–4.42)

5.86 (5.65–6.08)

6.51 (6.10–6.94)

6.92 (6.34–7.57)

10.30 (9.91–10.70)

Men

50,55

0.45 (0.41–0.49)

0.41 (0.37–0.46)

0.52 (0.41–0.67)

0.40 (0.23–0.71)

0.62 (0.30–1.30)

0.80 (0.57–1.13)

 

55,60

1.07 (1.01–1.14)

0.93 (0.86–1.01)

1.05 (0.91–1.22)

1.10 (0.87–1.40)

1.64 (1.26–2.14)

2.11 (1.79–2.49)

 

60,65

2.79 (2.68–2.89)

2.44 (2.30–2.58)

2.80 (2.60–3.02)

2.96 (2.65–3.31)

3.05 (2.68–3.48)

3.96 (3.60–4.36)

 

65,70

5.84 (5.68–6.01)

5.37 (5.10–5.66)

5.37 (5.07–5.69)

5.51 (5.11–5.95)

6.39 (5.93–6.89)

7.70 (7.20–8.23)

 

70,75

11.88 (11.64–12.14)

11.39 (10.83–11.98)

10.99 (10.51–11.49)

11.15 (10.61–11.73)

11.71 (11.19–12.26)

14.72 (14.05–15.41)

 

All

3.95 (3.89–4.01)

2.22 (2.15–2.29)

4.29 (4.13–4.46)

5.72 (5.50–5.96)

7.33 (7.05–7.61)

7.27 (7.03–7.52)

  1. *Exposure groups based on cardiovascular risk (CVR) at baseline: low (Framingham-REGICOR < 5%), low-intermediate (5% ≤ Framingham-REGICOR < 7.5%), high-intermediate (7.5% ≤ Framingham-REGICOR < 10%), high (Framingham-REGICOR ≥ 10%), and patients with history of vascular disease before the baseline