Prevalence and trend of central nervous system–active medication polypharmacy among US commercially insured adults with vs without early-onset dementia: a multi-year cross-sectional study

Table 2 Combinations of CNS-active medications concurrently used among adults with early-onset dementia who had CNS Polypharmacy

Additional medication class	Percentage of 8,960 patients with CNS-active medication polypharmacy
Additional medication class	Overall^a	Antidepressant^b	Benzodiazepine^b	Anticonvulsant^b	Antipsychotic^b	Opioid^b	Z-drug^b
Antidepressant	93.7	60.9	56.1	44.2	44.4	37.0	18.5
Benzodiazepine	57.2		11.2	39.2	44.2	36.0	18.2
Anticonvulsant	46.4			24.4	39.2	35.2	15.0
Antipsychotic	45.0				16.9	25.7	14.6
Opioid	38.3					25.8	20.2
Z-drug	19.3						2.3

Abbreviations: CNS central nervous system
^aPercentages of 10,970 patients with CNS-active medication polypharmacy with co-use of a specific therapeutic class of CNS medications
^bPercentages of 10,970 patients with CNS polypharmacy prescribed a specific combination of CNS-active medications within or between therapeutic classes. A patient may have more than one drug combination

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