Table 1 Demographic and clinical characteristics of commercially insured adults with early-onset dementia overall and by receipt of central nervous system polypharmacy
Characteristic | Overall sample No. (%) | With CNS polypharmacy No. (%) | Without CNS polypharmacy No. (%) | P value |
|---|---|---|---|---|
Overall | 37,563 (100) | 8,960 (100) | 28,603 (100) | |
Age, y | .019 | |||
Mean (SD) | 55.9 (7.0) | 56.0 (6.9) | 55.9 (7.1) | |
≤ 44 | 3532 (9.4) | 777 (8.7) | 2755 (9.6) | |
45–49 | 3463 (9.2) | 839 (9.4) | 2624 (9.2) | |
50–54 | 5764 (15.3) | 1373 (15.3) | 4391 (15.4) | |
55–59 | 9468 (15.6) | 2346 (26.2) | 7122 (24.9) | |
60–64 | 15336 (40.8) | 3625 (40.5) | 11,711 (40.9) | |
Sex | < .001 | |||
Male | 16,279 (43.3) | 3225 (36.0) | 13,054 (45.6) | |
Female | 21,284 (56.7) | 5735 (64.0) | 15,549 (54.4) | |
Locale | .078 | |||
Metropolitan | 27,138 (72.3) | 6408 (71.5) | 20,730 (72.5) | |
Rural | 10,425 (27.8) | 2552 (28.5) | 7873 (27.5) | |
US Region | < .001 | |||
Northeast | 7618 (20.3) | 1473 (16.4) | 6145 (21.5) | |
Midwest | 8025 (21.4) | 1965 (21.9) | 6060 (21.2) | |
South | 17,316 (46.1) | 4496 (50.2) | 12,820 (44.8) | |
West | 4604 (12.3) | 1026(11.5) | 3578 (12.5) | |
Clinical condition | ||||
Depression | 18,019 (48.0) | 7048 (78.7) | 10,971 (38.4) | < .001 |
Psychotic disorder | 2642 (7.0) | 1235 (13.8) | 1407 (4.9) | < .001 |
Behavioral symptoms | 7361 (19.6) | 2679 (29.9) | 4682 (16.4) | < .001 |
Chronic pain | 16,346 (43.5) | 5326 (59.4) | 11,020 (38.5) | < .001 |
Epilepsy | 4327 (11.5) | 1742 (19.4) | 2585 (9.0) | < .001 |
Injury | 3916 (10.4) | 1500 (16.7) | 2416 (8.5) | < .001 |
Substance use disorder | 4459 (11.9) | 1897 (21.2) | 2562 (9.0) | < .001 |
CCI (Mean ± SD) | 2.2 ± 2.0 | 2.7 ± 2.1 | 2.0 ± 1.9 | < .001 |
Subtype of indexed ADRD diagnosis | < .001 | |||
Dementia with Lewy bodies | 495 (1.3) | 145 (1.6) | 350 (1.2) | |
Frontotemporal dementia | 1160 (3.1) | 246 (2.8) | 914 (3.2) | |
Vascular dementia | 3132 (8.3) | 821 (9.2) | 2303 (8.1) | |
AD/senile dementia | 5333 (14.2) | 965 (10.7) | 4368 (15.3) | |
Dementia unspecified | 27451 (73.1) | 6783 (75.7) | 20668 (72.3) | |
Year of indexed ADRD diagnosis | 0.002 | |||
2013 | 6020 (16.0) | 1428 (15.9) | 4592 (16.1) | |
2014 | 4898 (13.0) | 1158 (12.9) | 3740 (13.1) | |
2015 | 5640 (15.0) | 1396 (15.6) | 4244 (14.8) | |
2016 | 5487 (14.6) | 1348 (15.0) | 4139 (14.5) | |
2017 | 4325 (11.5) | 1048 (11.7) | 3277 (11.5) | |
2018 | 4070 (10.8) | 951 (10.6) | 3119 (10.9) | |
2019 | 3879 (10.3) | 821 (9.2) | 3058 (10.7) | |
2020 | 3244 (8.6) | 810 (9.0) | 2434 (8.5) |