The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study

Table 2 Multiple linear regression of plasma NfL, P-tau181 with eGFR

Plasma biomarkers	Model 1^a			Model 2^b			Model 3^c
Plasma biomarkers	B (95% CI)	Standardized B (95% CI)	P value	B (95% CI)	Standardized B (95% CI)	P value	B (95% CI)	Standardized B (95% CI)	P value
NfL	− 0.190 (− 0.224, − 0.156)	− 0.304 (− 0.358, − 0.25)	< 0.001	− 0.093 (− 0.126, − 0.060)	− 0.149 (− 0.201, − 0.097)	< 0.001	− 0.100 (− 0.133, − 0.068)	− 0.16 (− 0.212, − 0.108)	< 0.001
P-tau181	− 0.009 (− 0.013, − 0.005)	− 0.127 (− 0.184, − 0.071)	< 0.001	− 0.003 (− 0.007, 0.001)	− 0.037 (− 0.095, 0.021)	0.214	− 0.003 (− 0.007, 0.001)	− 0.039 (− 0.097, 0.02)	0.194

Abbreviations: NfL neurofilament light chain, P-tau181 tau phosphorylated at threonine
^aModel 1 is a simple linear regression model
^bIn model 2, data were adjusted for demographic characteristics including gender, age, education, BMI, and APOE genotype
^cIn model 3, data were adjusted for demographic characteristics and comorbid diseases, eg. hypertension, diabetes, and stroke

ISSN: 1758-9193