Table 1 Demographics and clinical characteristics of study participants
|  | All participants n = 1189 | eGFR ≥ 90 n = 195 | 60 ≤ eGFR < 90 n = 796 | eGFR < 60 n = 198 | P value |
|---|---|---|---|---|---|
Characteristics | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) | Â |
Sex, female | 644 (54.2) | 117 (60.0) | 422 (53.0) | 105 (53.0) | 0.202 |
Age, years | 70.24 (64.32, 75.88) | 65.21 (62.79, 69.91) | 70.42 (64.68, 75.69) | 75.56 (69.70, 79.83) |  < 0.001 |
Education, years | 12.00 (9.00, 15.00) | 12.0 (9.00, 15.00) | 12.00 (9.00, 15.00) | 12.00 (9.00, 15.00) | 0.767 |
BMI, kg/m2 | 24.68 (22.55, 27.05) | 24.39 (22.44, 26.56) | 24.61 (22.59, 27.07) | 25.39 (22.96, 27.20) | 0.227 |
APOE ε4 carrier | 202 (17.0) | 31 (15.9) | 140 (17.6) | 31 (15.7) | 0.735 |
Stroke | 154 (13.0) | 19 (9.8) | 103 (12.9) | 32 (16.2) | 0.164 |
Hypertension | 621 (52.2) | 109 (55.9) | 401 (50.4) | 111 (56.1) | 0.191 |
Diabetes | 167 (14.1) | 33 (16.9) | 109 (13.7) | 25 (12.6) | 0.410 |
MMSE | 29 (28.00, 30.00) | 29.00 (28.00, 30.00) | 29.00 (28.00, 30.00) | 29.00 (27.00, 29.50) | 0.007 |
Domain-specific | |||||
 Memorya | 0.03 (− 0.67, 0.62) | 0.24 (− 0.36, 0.73) |  − 0.05 (− 0.60, 0.62) |  − 0.11 (− 0.96, 0.41) |  < 0.001 |
 Visuospatial abilitya |  − 0.34 (− 0.75, 0.46) | 0.06 (− 0.75, 0.46) |  − 0.34 (− 0.75, 0.56) |  − 0.34 (− 0.75, 0.46) | 0.028 |
 Attentiona | 0.016 (− 0.65, 0.56) | 0.18 (− 0.40, 0.89) |  − 0.03 (− 0.68, 0.56) |  − 0.08 (− 0.94, 0.49) |  < 0.001 |
 Executive functiona | 0.21 (− 0.23, 0.57) | 0.35 (− 0.01, 0.65) | 0.20 (− 0.20, 0.56) | 0.08 (− 0.56, 0.49) |  < 0.001 |
 Languagea | 0.46 (− 0.30, 0.85) | 0.46 (− 0.30, 0.85) | 0.46 (− 0.30, 0.85) | 0.08 (− 0.68, 0.85) | 0.018 |
 CysC (mg/l) | 1.00 (0.88, 1.14) | 0.79 (0.73, 0.84) | 1.00 (0.93, 1.09) | 1.33 (1.22, 1.46) |  < 0.001 |
 Creatinine (mg/dl) | 0.86 (0.72, 1.01) | 0.68 (0.60, 0.76) | 0.85 (0.75, 0.97) | 1.13 (0.98, 1.27) |  < 0.001 |
 Uric acid (mg/dl) | 334.00 (285.50, 388.00) | 295.00 (254.00, 343.00) | 331.50 (286.00, 379.00) | 389.00 (325.75, 452.00) |  < 0.001 |
 Plasma NfL (pg/ml) | 15.50 (11.83, 21.38) | 12.27 (9.73, 16.73) | 15.50 (11.94, 20.25) | 20.70 (15.17, 28.25) |  < 0.001 |
 Plasma P-tau181 (pg/ml) | 1.91 (1.49, 2.47) | 1.74 (1.39, 2.20) | 1.90 (1.50,2.44) | 2.17 (1.65, 2.77) |  < 0.001 |
 eGFR (ml/min/1.73 m2) | 74.78 (64.53, 85.55) | 95.93 (92.42, 100.28) | 74.84 (68.79, 82.07) | 52.36 (48.00, 56.00) |  < 0.001 |