Fig. 3
Forest plots of subgroups and interaction analysis. Forest plots illustrated the association between eGFR and plasma biomarker levels in different subgroups. The value of P interaction demonstrated whether the association between eGFR and plasma biomarker levels was modulated by demographic characteristics and co-morbid diseases. Since the concentrations of plasma NfL and P-tau181 differed by magnitude, the raw plasma level was z score transformed for parallel comparison between the coefficients. Means and 95% confidence intervals were provided. In the multivariate model, data were adjusted for demographic characteristics and co-morbid diseases. Abbreviations: APOE, apolipoprotein E; BMI, body mass index; NfL, neurofilament light chain; P-tau181, tau phosphorylated at threonine 181