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Table 1 Demographic and clinical characteristics of the study participants

From: Plasma oligomer beta-amyloid is associated with disease severity and cerebral amyloid deposition in Alzheimer’s disease spectrum

 

A-PET negative NC (N = 39)

A-PET negative MCI (N = 31)

A-PET positive MCI (N = 30)

AD dementia (N = 22)

P value

Age (years ± SD)

73.05 (5.68)

75.68 (6.41)

77.27 (7.22)

77.77 (6.93)

0.02

Post hoca

NC < PET − MCI, PET + MCI, and AD dementia; others no statistical difference

Education (years ± SD)

11.82 (4.56)

9.14 (4.71)

10.90 (5.40)

9.50 (6.07)

NS

Sex (M:F)

10:29

9:22

13:17

8:14

NS

SUVR (mean ± SD)

0.50 (0.076)

0.51 (0.069)

0.75 (0.081)

0.795 (0.094)

 < .001

Post hoca

NC = PET − MCI < PET + MCI and AD dementia

  APOE4 (%)

12.8

19.4

56.7

57.1

 < .001

CERAD-K Battery (SD)

  VF

14.77 (4.05)

10.32 (4.23)

10.63 (2.74)

5.96 (3.15)

 < .001

  BNT

12.67 (1.72)

9.39 (3.32)

10.53 (2.33)

7.09 (3.96)

 < .001

  MMSE

28.23 (1.69)

23.36 (3.56)

22.27 (3.36)

16.14 (4.99)

 < .001

  WLM

18.69 (3.29)

13.94 (3.23)

13.37 (3.41)

8.77 (4.15)

 < .001

  CP

9.97 (1.29)

8.68 (1.81)

9.47 (1.74)

8.27 (2.33)

 < .001

  WLR

6.15 (1.44)

3.42 (1.65)

2.53 (1.87)

1.32 (1.43)

 < .001

  WLRc

9.23 (1.11)

7.23 (2.26)

6.13 (2.27)

3.32 (2.21)

 < .001

  CR

7.28 (2.32)

3.45 (2.38)

2.53 (3.25)

1.5 (2.24)

 < .001

  CERAD total score

71.49 (9.25)

52.97 (11.12)

52.67 (8.92)

34.73 (12.65)

 < .001

  1. aBonferroni corrected for multiple corrections
  2. BNT 15-Item Boston Naming Test, CERAD-K The Korean Version of Consortium to Establish A Registry For Alzheimer’s Disease, CDR Clinical Dementia Rating, CP Constructional Praxis, CR constructional recall, MMSE Mini-Mental Status Examination, NS not significant, SD standard deviation, VF verbal fluency, WLRc word list recognition, WLM word list memory, WLR word list recall