Odds of being transitioned to long-term care facilities | Unimpaired cognition | MCI due to AD | Mild AD dementia | Moderate AD dementia | Severe AD dementia | |||||
---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
Visit number | ||||||||||
Visit 2 | 1.20 (0.88, 1.63) | 0.250 | 1.99 (1.53, 2.58) | < .0001 | 2.25 (1.94, 2.60) | < .0001 | 2.11 (1.73, 2.57) | < .0001 | 1.32 (1.06, 1.65) | 0.014 |
Visit 3 | 1.35 (0.96, 1.91) | 0.084 | 2.95 (2.20, 3.95) | < .0001 | 3.30 (2.78, 3.92) | < .0001 | 2.90 (2.22, 3.79) | < .0001 | 1.78 (1.28, 2.48) | 0.001 |
Visit 4 | 1.31 (0.91, 1.88) | 0.143 | 4.21 (3.10, 5.71) | < .0001 | 4.85 (4.00, 5.89) | < .0001 | 4.73 (3.39, 6.59) | < .0001 | 1.68 (1.06, 2.65) | 0.026 |
Visit 5 | 1.25 (0.85, 1.84) | 0.251 | 5.73 (4.15, 7.91) | < .0001 | 6.12 (4.90, 7.65) | < .0001 | 5.02 (3.26, 7.72) | < .0001 | 1.85 (0.98, 3.50) | 0.059 |
Visit 6 | 1.49 (1.00, 2.22) | 0.050 | 8.78 (6.31, 12.21) | < .0001 | 6.59 (5.07, 8.56) | < .0001 | 7.01 (4.14, 11.86) | < .0001 | 1.26 (0.53, 2.96) | 0.602 |
Visit 1 | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Age | 1.19 (1.16, 1.23) | < .0001 | 1.09 (1.07, 1.10) | < .0001 | 1.04 (1.03, 1.05) | < .0001 | 1.03 (1.01, 1.04) | 0.001 | 1.01 (1.00, 1.03) | 0.126 |
Race | ||||||||||
Black/African American | 0.43 (0.20, 0.92) | 0.029 | 0.45 (0.27, 0.74) | 0.002 | 0.47 (0.31, 0.71) | 0.000 | 0.42 (0.26, 0.68) | 0.001 | 0.26 (0.12, 0.53) | 0.000 |
Hispanic | 0.99 (0.36, 2.68) | 0.978 | 0.45 (0.19, 1.07) | 0.070 | 0.42 (0.26, 0.69) | 0.001 | 0.16 (0.08, 0.33) | < .0001 | 0.25 (0.13, 0.45) | < .0001 |
Othersa | 1.85 (0.49, 6.91) | 0.363 | 0.50 (0.20, 1.26) | 0.141 | 1.17 (0.63, 2.15) | 0.622 | 0.30 (0.08, 1.19) | 0.088 | 0.73 (0.19, 2.80) | 0.645 |
White | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Sex | ||||||||||
Male | 0.74 (0.50, 1.09) | 0.125 | 0.48 (0.38, 0.62) | < .0001 | 0.56 (0.46, 0.69) | < .0001 | 0.94 (0.68, 1.30) | 0.708 | 0.95 (0.68, 1.34) | 0.788 |
Female | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Education | ||||||||||
Bachelor’s degree | 1.43 (0.92, 2.22) | 0.110 | 1.09 (0.80, 1.48) | 0.576 | 1.01 (0.78, 1.31) | 0.918 | 1.33 (0.85, 2.07) | 0.215 | 1.31 (0.78, 2.19) | 0.306 |
High school or GRE | 1.49 (0.90, 2.47) | 0.124 | 1.20 (0.87, 1.67) | 0.267 | 0.75 (0.56, 0.99) | 0.039 | 1.51 (0.98, 2.32) | 0.060 | 1.00 (0.59, 1.68) | 0.986 |
Less than high school | 0.84 (0.29, 2.44) | 0.747 | 0.93 (0.52, 1.69) | 0.819 | 0.48 (0.30, 0.76) | 0.002 | 1.52 (0.85, 2.72) | 0.159 | 1.05 (0.54, 2.04) | 0.875 |
Some college | 1.01 (0.60, 1.71) | 0.957 | 0.72 (0.50, 1.04) | 0.079 | 0.93 (0.69, 1.24) | 0.606 | 1.58 (0.97, 2.58) | 0.066 | 0.82 (0.46, 1.45) | 0.489 |
Master’s degree or doctorate | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Cerebrovascular disease | ||||||||||
No | 0.47 (0.28, 0.78) | 0.004 | 0.70 (0.42, 1.18) | 0.182 | 0.83 (0.54, 1.25) | 0.365 | 0.57 (0.34, 0.95) | 0.031 | 0.98 (0.54, 1.78) | 0.945 |
Unknown/missing | 1.10 (0.59, 2.05) | 0.773 | 2.43 (1.38, 4.27) | 0.002 | 2.63 (1.65, 4.19) | < .0001 | 1.46 (0.79, 2.68) | 0.225 | 1.69 (0.68, 4.19) | 0.256 |
Yes | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Diabetes | ||||||||||
No | 1.28 (0.58, 2.84) | 0.535 | 1.49 (0.92, 2.42) | 0.104 | 1.37 (0.80, 2.35) | 0.259 | 4.11 (1.58, 10.72) | 0.004 | 0.32 (0.10, 1.07) | 0.065 |
Unknown/missing | 1.38 (0.56, 3.43) | 0.485 | - | 1.41 (0.77, 2.59) | 0.262 | 3.43 (1.26, 9.38) | 0.016 | 0.41 (0.12, 1.42) | 0.159 | |
Yes | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Depression | ||||||||||
No | 0.65 (0.44, 0.98) | 0.039 | 1.00 (1.00, 1.00) | 0.94 (0.78, 1.14) | 0.549 | 0.88 (0.65, 1.20) | 0.431 | 1.20 (0.81, 1.77) | 0.373 | |
Yes | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
Anxiety | ||||||||||
No | 0.46 (0.31, 0.69) | 0.000 | 1.03 (0.83, 1.26) | 0.813 | 1.54 (1.33, 1.80) | < .0001 | 1.67 (1.31, 2.13) | < .0001 | 2.41 (1.81, 3.20) | < .0001 |
Unknown/missing | 0.76 (0.36, 1.58) | 0.462 | 2.72 (1.56, 4.75) | 0.000 | 4.28 (2.77, 6.62) | < .0001 | 3.06 (1.66, 5.65) | 0.000 | 4.70 (2.93, 7.54) | < .0001 |
Yes | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |