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Table 4 Adjusted analyses of being transitioned to long-term care facilities over time by CDR stage at initial visit

From: Relationships of change in Clinical Dementia Rating (CDR) on patient outcomes and probability of progression: observational analysis

Odds of being transitioned to long-term care facilities

Unimpaired cognition

MCI due to AD

Mild AD dementia

Moderate AD dementia

Severe AD dementia

 

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Visit number

 Visit 2

1.20 (0.88, 1.63)

0.250

1.99 (1.53, 2.58)

 < .0001

2.25 (1.94, 2.60)

 < .0001

2.11 (1.73, 2.57)

 < .0001

1.32 (1.06, 1.65)

0.014

 Visit 3

1.35 (0.96, 1.91)

0.084

2.95 (2.20, 3.95)

 < .0001

3.30 (2.78, 3.92)

 < .0001

2.90 (2.22, 3.79)

 < .0001

1.78 (1.28, 2.48)

0.001

 Visit 4

1.31 (0.91, 1.88)

0.143

4.21 (3.10, 5.71)

 < .0001

4.85 (4.00, 5.89)

 < .0001

4.73 (3.39, 6.59)

 < .0001

1.68 (1.06, 2.65)

0.026

 Visit 5

1.25 (0.85, 1.84)

0.251

5.73 (4.15, 7.91)

 < .0001

6.12 (4.90, 7.65)

 < .0001

5.02 (3.26, 7.72)

 < .0001

1.85 (0.98, 3.50)

0.059

 Visit 6

1.49 (1.00, 2.22)

0.050

8.78 (6.31, 12.21)

 < .0001

6.59 (5.07, 8.56)

 < .0001

7.01 (4.14, 11.86)

 < .0001

1.26 (0.53, 2.96)

0.602

 Visit 1

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

 Age

1.19 (1.16, 1.23)

 < .0001

1.09 (1.07, 1.10)

 < .0001

1.04 (1.03, 1.05)

 < .0001

1.03 (1.01, 1.04)

0.001

1.01 (1.00, 1.03)

0.126

Race

 Black/African American

0.43 (0.20, 0.92)

0.029

0.45 (0.27, 0.74)

0.002

0.47 (0.31, 0.71)

0.000

0.42 (0.26, 0.68)

0.001

0.26 (0.12, 0.53)

0.000

 Hispanic

0.99 (0.36, 2.68)

0.978

0.45 (0.19, 1.07)

0.070

0.42 (0.26, 0.69)

0.001

0.16 (0.08, 0.33)

 < .0001

0.25 (0.13, 0.45)

 < .0001

 Othersa

1.85 (0.49, 6.91)

0.363

0.50 (0.20, 1.26)

0.141

1.17 (0.63, 2.15)

0.622

0.30 (0.08, 1.19)

0.088

0.73 (0.19, 2.80)

0.645

 White

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Sex

 Male

0.74 (0.50, 1.09)

0.125

0.48 (0.38, 0.62)

 < .0001

0.56 (0.46, 0.69)

 < .0001

0.94 (0.68, 1.30)

0.708

0.95 (0.68, 1.34)

0.788

 Female

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Education

 Bachelor’s degree

1.43 (0.92, 2.22)

0.110

1.09 (0.80, 1.48)

0.576

1.01 (0.78, 1.31)

0.918

1.33 (0.85, 2.07)

0.215

1.31 (0.78, 2.19)

0.306

 High school or GRE

1.49 (0.90, 2.47)

0.124

1.20 (0.87, 1.67)

0.267

0.75 (0.56, 0.99)

0.039

1.51 (0.98, 2.32)

0.060

1.00 (0.59, 1.68)

0.986

 Less than high school

0.84 (0.29, 2.44)

0.747

0.93 (0.52, 1.69)

0.819

0.48 (0.30, 0.76)

0.002

1.52 (0.85, 2.72)

0.159

1.05 (0.54, 2.04)

0.875

 Some college

1.01 (0.60, 1.71)

0.957

0.72 (0.50, 1.04)

0.079

0.93 (0.69, 1.24)

0.606

1.58 (0.97, 2.58)

0.066

0.82 (0.46, 1.45)

0.489

 Master’s degree or doctorate

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Cerebrovascular disease

 No

0.47 (0.28, 0.78)

0.004

0.70 (0.42, 1.18)

0.182

0.83 (0.54, 1.25)

0.365

0.57 (0.34, 0.95)

0.031

0.98 (0.54, 1.78)

0.945

 Unknown/missing

1.10 (0.59, 2.05)

0.773

2.43 (1.38, 4.27)

0.002

2.63 (1.65, 4.19)

 < .0001

1.46 (0.79, 2.68)

0.225

1.69 (0.68, 4.19)

0.256

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Diabetes

 No

1.28 (0.58, 2.84)

0.535

1.49 (0.92, 2.42)

0.104

1.37 (0.80, 2.35)

0.259

4.11 (1.58, 10.72)

0.004

0.32 (0.10, 1.07)

0.065

 Unknown/missing

1.38 (0.56, 3.43)

0.485

-

 

1.41 (0.77, 2.59)

0.262

3.43 (1.26, 9.38)

0.016

0.41 (0.12, 1.42)

0.159

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Depression

 No

0.65 (0.44, 0.98)

0.039

1.00 (1.00, 1.00)

 

0.94 (0.78, 1.14)

0.549

0.88 (0.65, 1.20)

0.431

1.20 (0.81, 1.77)

0.373

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Anxiety

 No

0.46 (0.31, 0.69)

0.000

1.03 (0.83, 1.26)

0.813

1.54 (1.33, 1.80)

 < .0001

1.67 (1.31, 2.13)

 < .0001

2.41 (1.81, 3.20)

 < .0001

 Unknown/missing

0.76 (0.36, 1.58)

0.462

2.72 (1.56, 4.75)

0.000

4.28 (2.77, 6.62)

 < .0001

3.06 (1.66, 5.65)

0.000

4.70 (2.93, 7.54)

 < .0001

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

  1. aAmerican Indian or Alaska Native and Native Hawaiian or other Pacific Islanders
  2. Ref the reference standard to which other data are compared