Table 3 Changes in CDR stages from the prior visit and corresponding changes in selected outcomes of interest

NACC-FAS

 Unimpaired cognition

0.09 (− 0.05, 0.23)

1.25 (1.01, 1.49)

17.12 (15.92, 18.32)

20.52 (17.61, 23.44)

30.00 (27.62, 30.00)

 MCI due to AD

–

1.41 (1.26, 1.56)

6.99 (6.79, 7.19)

11.85 (11.39, 12.32)

18.88 (17.90, 19.86)

 Mild AD dementia

–

–

2.59 (2.43, 2.75)

4.65 (4.47, 4.83)

6.32 (5.99, 6.65)

 Moderate AD dementia

–

–

–

1.44 (1.27, 1.61)

1.46 (1.27, 1.66)

 Severe dementia

–

–

–

–

0.19 (0.03, 0.35)

GDS

 Unimpaired cognition

0.21 (0.14, 0.29)

0.60 (0.48, 0.72)

1.10 (0.49, 1.71)

2.02 (− 0.30, 4.33)

 MCI due to AD

–

0.14 (0.06, 0.21)

0.11 (0.01, 0.21)

0.05 (− 0.19, 0.30)

 − 0.91 (− 2.22, 0.40)

 Mild AD dementia

–

–

 − 0.01 (− 0.09, 0.07)

0.01 (− 0.09, 0.12)

0.13 (− 0.17, 0.43)

 Moderate AD dementia

–

–

–

0.05 (− 0.05, 0.15)

0.12 (− 0.08, 0.32)

 Severe AD dementia

–

–

–

–

0.28 (0.02, 0.54)

NPI-Q

 Unimpaired cognition

0.43 (0.35, 0.51)

1.04 (0.84, 1.23)

3.93 (2.93, 4.94)

2.22 (− 0.59, 5.03)

1.34 (− 1.58, 4.26)

 MCI due to AD

–

0.30 (0.21, 0.39)

1.06 (0.93, 1.19)

2.64 (2.29, 2.98)

3.99 (3.20, 4.79)

 Mild AD dementia

–

–

0.12 (0.02, 0.21)

1.27 (1.14, 1.40)

3.06 (2.76, 3.36)

 Moderate AD dementia

–

–

–

0.32 (0.20, 0.44)

1.01 (0.84, 1.18)

 Severe AD dementia

–

–

–

–

 − 0.51 (− 0.63, − 0.38)

MMSE

 Unimpaired cognition

0.01 (− 0.60, 0.61)

 − 0.67 (− 1.30, − 0.04)

 − 4.08 (− 5.22, − 2.95)

 − 8.68 (− 12.03, − 5.32)

–

 MCI due to AD

–

 − 0.61 (− 1.22, − 0.01)

 − 2.54 (− 3.15, − 1.92)

 − 6.22 (− 6.94, − 5.51)

 − 8.11 (− 9.64, − 6.58)

 Mild AD dementia

–

–

 − 1.43 (− 2.04, − 0.82)

 − 4.25 (− 4.87, − 3.64)

 − 8.62 (− 9.32, − 7.91)

 Moderate AD dementia

–

–

–

 − 2.18 (− 2.80, − 1.57)

 − 4.95 (− 5.59, − 4.31)

 Severe AD dementia

–

–

–

–

 − 1.69 (− 2.32, − 1.06)

MoCA

 Unimpaired cognition

 − 0.26 (− 0.85, 0.33)

 − 1.44 (− 2.11, − 0.77)

 − 0.51 (− 4.06, 3.04)

–

–

 MCI due to AD

–

 − 1.10 (− 1.70, − 0.51)

 − 3.08 (− 3.70, − 2.45)

 − 6.58 (− 7.54, − 5.63)

 − 7.40 (− 12.64, − 2.15)

 Mild AD dementia

–

–

 − 2.16 (− 2.76, − 1.57)

 − 4.32 (− 4.96, − 3.68)

 − 6.05 (− 7.21, − 4.90)

 Moderate AD dementia

–

–

–

 − 2.34 (− 3.00, − 1.68)

 − 3.21 (− 4.20, − 2.23)

 Severe AD dementia

–

–

–

–

 − 5.02 (− 6.56, − 3.48)