Table 2 Changes in CDR from baseline to visit 6 and corresponding changes in selected outcomes of interest

NACC-FAS

 Unimpaired cognition

2.6 (0.2, 5.0)

6.2 (3.8, 8.7)

21.0 (18.5, 23.4)

30.4 (27.2, 33.6)

30.0 (28.4, 30.0)

 MCI due to AD

–

5.2 (2.8, 7.7)

16.9 (14.4, 19.3)

22.5 (20.1, 25.0)

23.3 (20.8, 25.8)

 Mild AD dementia

–

–

10.8 (8.2, 13.5)

13.8 (11.3, 16.3)

13.9 (11.4, 16.3)

 Moderate AD dementia

–

–

–

6.3 (2.0, 10.7)

6.6 (4.1, 9.1)

 Severe AD dementia

–

–

–

–

4.2 (1.5, 6.9)

GDS

 Unimpaired cognition

0.2 (− 1.3, 1.7)

0.9 (− 0.6, 2.4)

1.1 (− 0.5, 2.6)

2.2 (0.4, 4.0)

−

 MCI due to AD

–

0.1 (− 1.4, 1.6)

 − 0.2 (− 1.7, 1.3)

 − 0.2 (− 1.7, 1.3)

0.6 (− 1.2, 2.3)

 Mild AD dementia

–

–

 − 0.4 (− 2.0, 1.1)

 − 0.4 (− 1.9, 1.2)

 − 0.3 (− 2.0, 1.3)

 Moderate AD dementia

–

–

–

 − 0.3 (− 2.5, 1.9)

0.9 (− 1.2, 2.9)

 Severe AD dementia

–

–

–

–

6.9 (3.0, 10.8)

NPI-Q

 Unimpaired cognition

 − 0.6 (− 2.4, 1.1)

0.8 (− 1.0, 2.6)

3.0 (1.2, 4.9)

4.5 (2.0, 6.9)

1.9 (− 1.7, 5.5)

 MCI due to AD

–

0.1 (− 1.7, 1.9)

1.0 (− 0.8, 2.7)

3.3 (1.5, 5.1)

2.7 (0.9, 4.5)

 Mild AD dementia

–

–

 − 0.2 (− 2.0, 1.7)

2.1 (0.3, 3.9)

2.6 (0.8, 4.4)

 Moderate AD dementia

–

–

–

1.2 (− 2.2, 4.5)

0.0 (− 1.9, 1.8)

 Severe AD dementia

–

–

– 

– 

 − 1.3 (− 3.5, 0.9)

MMSE

 Unimpaired cognition

1.1 (− 0.9, 3.1)

 − 0.1 (− 2.2, 1.9)

 − 5.2 (− 7.3, − 3.0)

 − 10.7 (− 13.4, − 8.1)

–

 MCI due to AD

–

 − 0.6 (− 2.6, 1.5)

 − 3.1 (− 5.1, − 1.0)

 − 9.1 (− 11.2, − 7.0)

 − 16.5 (− 18.7, − 14.3)

 Mild AD dementia

–

–

 − 2.3 (− 4.4, − 0.1)

 − 6.2 (− 8.3, − 4.2)

 − 14.5 (− 16.6, − 12.4)

 Moderate AD dementia

–

–

–

 − 2.1 (− 5.2, 0.9)

 − 5.5 (− 7.9, − 3.1)

 Severe AD dementia

–

–

–

–

 − 8.9 (− 13.0, − 4.9)