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Table 2 GCL and RNFL thickness meta-analysis: top concordant signals across datasets and eyes

From: Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort

Top SNP

RS

Total SNPs

kb

A1

P meta

BETA

Q

I

Triton

Maestro

Nearest genes (200 kb)

Left eye

Right eye

Left eye

Right eye

GCIPL thickness

 5:152625167:A:C

rs11167584

17

13.6

C

2.3e−10

−1.31

7.6e−01

0

−1.24

−1.68

−1.25

−1.04

LOC101927134(0)

 3:120804007:C:CG

rs373444630

1

0.0

CG

5.3e−09

1.07

9.9e−01

0

1.06

1.09

1.17

0.96

GTF2E1(+20.9 kb)| STXBP5L(−104.2 kb)

 17:81648542:A:G

rs7405453

1

0.0

A

5.9e−09

−1.06

3.7e−02

64.8

−1.5

−1.49

−0.41

−0.42

TSPAN10(0)

 6:154594197:T:C

rs2139855

1

0.0

T

9.5e−09

−1.03

7.5e−01

0

−1.3

−0.81

−0.96

−0.92

CNKSR3(+83.6 kb)|SCAF8(−139.2 kb)

 2:14362480:A:G

rs182487621

1

0.0

G

1.3e−08

−4.53

9.8e−01

0

−4.65

−3.92

−4.94

−4.66

LINC00276(0)

 22:16612526:C:T

rs11089268

25

57.7

T

3.7e−08

−1.19

8.2e−01

0

−1.22

−0.92

−1.52

−1.1

TPTEP1(0)

 18:27756533:T:C

rs147136024

1

0.0

C

4.1e−08

−4.2

4.2e−02

63.5

−7.02

−3.49

−3.13

−1.27

CDH2(−194.4 kb)

RNFL thickness

 1:110872670:C:T

rs61803955

4

2.7

T

1.0e−10

5.6

5.6e−02

60.34

6.3

3.6

8.2

12.0

CD53(0)

 1:60043219:G:A

rs149444168

7

231.1

A

2.1e−10

5.6

9.0e−03

74.08

7.9

2.5

7.6

10.7

C1orf87(0)

 5:105525900:A:G

NA

3

103.3

G

9.2e−10

5.8

2.4e−01

28.3

8.2

4.2

4.7

4.6

 

 8:42885667:A:C

rs143666229

3

139.4

C

4.9e−09

4.9

1.2e−01

49.03

7.4

3.4

2.6

2.6

RNF170(0)

 18:77673191:C:T

rs512467

4

1.3

C

5.2e−09

1.3

1.2e−01

47.93

2.0

0.9

0.6

1.2

 

 1:121516475:G:C

rs114500301

3

114.8

C

6.2e−09

5.7

5.7e−01

0

7.4

5.0

3.9

3.6

EMBP1(−2.6 kb)|SRGAP2-AS1(+118.6 kb)

 12:24137871:T:C

rs12372308

2

0.0

C

7.3e−09

3.6

3.8e−03

77.63

5.4

1.2

5.3

7.6

SOX5(0)

 8:43806675:G:A

rs12681971

9

145.9

A

1.1e−08

4.8

1.5e−01

43.6

7.1

3.4

2.7

2.3

 

 2:9674766:C:G

rs16867115

10

9.4

G

1.5e−08

4.9

6.6e−02

58.25

7.8

2.7

3.8

6.1

TAF1B(−168.7 kb)|YWHAQ(+43.71 kb)

 10:132126425:C:T

rs2814187

2

0.0

C

1.5e−08

−1.2

1.7e−01

39.82

−1.5

−0.7

−2.2

−1.4

JAKMIP3(0)

 20:14267811:T:C

rs6105236

9

11.8

C

1.6e−08

1.5

8.8e−02

54.1

1.9

0.8

2.3

2.8

MACROD2(0)

 3:107833982:A:G

rs116535715

2

0.0

G

1.6e−08

5.2

3.9e−03

77.54

7.2

2.0

13.4

9.0

LINC00635(−7.7 kb)|LINC00636(−49.2 kb)

 11:43040082:C:T

rs148342611

3

57.8

T

3.6e−08

5.7

1.9e−01

36.21

8.1

3.4

5.3

7.2

 

 13:38256057:A:C

rs564689

49

28.1

C

4.0e−08

5.3

5.1e−02

61.48

8.7

2.9

5.0

3.5

LINC00571(+112.8 kb)|UFM1(−93.7 kb)

  1. Kb Kilobases, Q P-value for Cochrane’s Q statistic, I I2 heterogeneity index (0–100)