Table 1 Characteristics of the study population

Sex

< 0.001

< 0.001

 Male

547 (29.6%)

320 (41.9%)

180 (32.2%)

1047 (33.0%)

430 (27.7%)

117 (39.9%)

 Female

1300 (70.4%)

444 (58.1%)

379 (67.8%)

2123 (67.0%)

1124 (72.3%)

176 (60.1%)

Age (years)

< 0.001

0.305

 N

1847

764

559

3170

1554

293

 Median [Q1,Q3]

82.0 [77.0, 86.0]

74.0 [69.0, 80.0]

65.0 [59.0, 70.0]

78.0 [70.0, 84.0]

82.0 [77.0,86.0]

81.0 [76.0,86.0]

 Mean (sd)

80.72 (7.31)

64.57 (8.64)

73.55 (8.55)

76.14 (9.97)

80.8 (7.3)

80.3 (7.4)

Education (years)

< 0.001

0.459

 N

1784

721

295

2800

1501

283

 Median [Q1,Q3]

6.0 [3.0, 8.0]

6.0 [5.0, 10.0]

10.0 [8.0, 14.5]

6.0 [3.0, 10.0]

6.00 [3.0,8.0]

6.00 [3.0,8.0]

 Mean (sd)

5.93 (4.18)

11.39 (4.23)

7.55 (4.37)

6.92 (4.56)

5.9 (4.1)

6.2 (4.5)

MMSE score

< 0.001

< 0.001

 N

1837

761

557

3155

1544

293

 Median [Q1,Q3]

20.0 [17.0,23.0]

26.0 [24.0, 28.0]

30.0 [29.0, 30.0]

23.0 [19.0, 28.0]

19.0 [16.0, 23.0]

22.0 [18.0, 25.0]

 Mean (sd)

19.45 (4.75)

29.41 (0.86)

25.67 (3.11)

22.71 (5.65)

19.1 (4.8)

21.3 (4.3)

APOE genotype

< 0.001

< 0.001

 NA

7 (0.4%)

8 (1.0%)

1 (0.2%)

16 (0.5%)

5 (0.3%)

2 (0.7%)

 e2e2

7 (0.4%)

6 (0.8%)

1 (0.2%)

14 (0.4%)

5 (0.3%)

2 (0.7%)

 e2e3

105 (5.7%)

51 (6.7%)

63 (11.3%)

219 (6.9%)

81 (5.2%)

24 (8.2%)

 e2e4

29 (1.6%)

12 (1.6%)

11 (2.0%)

52 (1.6%)

27 (1.7%)

2 (0.7%)

 e3e3

985 (53.3%)

446 (58.4%)

348 (62.3%)

1779 (56.1%)

803 (51.7%)

182 (62.1%)

 e3e4

621 (33.6%)

211 (27.6%)

122 (21.8%)

954 (30.1%)

548 (35.3%)

73 (24.9%)

 e4e4

93 (5.0%)

30 (3.9%)

13 (2.3%)

136 (4.3%)

85 (5.5%)

8 (2.7%)

Comorbidities^a

 Amblyopia

33(1.8%)/31(1.7%)

14(1.8%)/24(3.1%)

17(3.0%)/10(1.8%)

64(2.0%)/65(2.1%)

0.166/0.050

29(1.9%)/27(1.7%)

4(1.4%)/4(1.4%)

0.553/0.649

 Surgery

33(1.8%)/35(1.9%)

34(4.5%)/39(5.1%)

34(6.1%)/35(6.3%)

101(3.2%)/109(3.4%)

< 0.001/ < 0.001

24(1.5%)/27(1.7%)

9(3.1%)/8(2.7%)

0.070/0.253

 AMD

22(1.2%)/24(1.3%)

12(1.6%)/12(1.6%)

0(0.0%)/2(0.4%)

34(1.1%)/38(1.2%)

0.017/0.111

19 (1.2%)/21(1.4%)

3(1.0%)/3(1.0%)

0.774/0.650

 Dps < -6 or >  + 6

2(0.1%)/2(0.1%)

0(0.0%)/0(0.0%)

0(0.0%)/0(0.0%)

2(0.1%)/2(0.1%)

0.488/0.488

2(0.1%)/2 (0.1%)

0(0.0%)/0(0.0%)

0.539/0.539

 Glaucoma

74(4.0%)/77(4.2%)

38(5.0%)/38(5.0%)

23(4.1%)/22(3.9%)

135(4.3%)/137(4.3%)

0.529/0.579

60(3.9%)/63(4.1%)

14(4.8%)/14(4.8%)

0.463/0.569

 IOP > 24 mmHg

30(1.6%)/29(1.6%)

13(1.7%)/19(2.5%)

14(2.5%)/14(2.5%)

57(1.8%)/62(2.0%)

0.380/0.180

24(1.5%)/21(1.4%)

6(2.0%)/8(2.7%)

0.532/0.082

 Other

8(0.4%)/8(0.4%)

7(0.9%)/5(0.7%)

3(0.5%)/3(0.5%)

18(0.6%)/16(0.5%)

0.325/0.763

8(0.5%)/7(0.5%)

0(0.0%)/1(0.3%)

0.218/0.794

GCIPL^a

< 0.001/ < 0.001

0.127/0.842

 N

1727/1765

700/713

529/536

2956/3004

1446/1470

281/285

 Median [Q1,Q3]

61.5[55.8,66.5]/61.6[55.3,66.4]

64.4[59.0,69.4]/64.6[58.8,69.5]

64.4[60.6,68.1]/64.0[60.5,68.1]

62.8[57.4,67.5]/62.7[57.0,67.5]

61.3[55.7,66.4]/61.68[55.2,66.4]

62.2[56.2,67.0]/61.2[55.9,66.5]

 Mean (sd)

59.45(14.03)/58.47(14.85)

62.85(10.29)/62.67(10.27)

62.37(11.94)/62.2(12.72)

60.75(13.04)/60.11(13.77)

59.3(14.3)/58.4(14.8)

60.5(12.6)/58.7(15.3)

RNFL^a

< 0.001/ < 0.001

0.111/0.021

 N

1727/1755

700/713

529/536

2956/3004

1446/1470

281/285

 Median [Q1,Q3]

35.6[31.9,40.3]/36.5[32.6,42.0]

36.0[33.0,40.1]/36.7[33.3,41.6]

37.4[34.5,41.1]/38.7[35.1,42.6]

36.1[32.7,40.4]/37.0[33.3,42.0]

35.70[31.9,40.4]/36.6[32.9,42.20]

35.10[31.50,39.5]/35.8[31.7,41.0]

 Mean (sd)

39.36(20.78)/40.09(21.14)

41.23(17.26)/42.13(17.95)

41.46(20.39)/41.96(20.8)

40.19(20.12)/40.9(20.54)

39.8(21.7)/40.7(21.8)

37.0(15.4)/37.2(17.1)