Fig. 1

Plasma amyloid and phosphorylated Tau concentrations in the exploratory cohort according to cognitive status and progression. Concentrations depicted A Aβ42/Aβ40 ratio, B p-Tau181, and C p-Tau181/Aβ42 ratio. Data is presented in points as individual values and the spread of the distribution with quartiles and median by a boxplot categorized by NC (n = 22), MCI-St (n = 36), MCI-AD (n = 36), and AD dementia (n = 44). Group comparison was performed by Kruskal–Wallis test with a Bonferroni correction showing a p-value label of significance: *p < 0.05; **p < 0.01; ***p < 0.001; n.s., not significant. Abbreviations: Aβ, amyloid beta; AD, Alzheimer’s disease; MCI-AD, mild cognitive impairment that progressed to AD dementia; MCI-St, stable mild cognitive impairment; p-Tau181, phosphorylated tau protein in the position 181