Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Table 2 Associations of cardiometabolic disease status and CSF AD biomarkers in cognitively intact participants

Variable	Aβ42		P-tau181		T-tau		Aβ42/Aβ40		P-tau181 /Aβ42		T-tau/Aβ42
Variable	β	P value	β	P value	β	P value	β	P value	β	P value	β	P value
Number of CMD (continuous)	0.070	0.504	0.078	0.044	0.030	0.047	−0.007	0.637	0.007	0.879	0.012	0.661
CMD status
CMD-free (n = 700)	Ref.		Ref.		Ref.		Ref.		Ref.		Ref.
Single CMD (n = 454)	−0.036	0.840	0.047	0.475	0.009	0.721	−0.008	0.751	0.049	0.528	0.020	0.670
CMD multimorbidity (n = 310)	0.170	0.428	0.165	0.037	0.065	0.033	−0.014	0.650	0.002	0.981	0.022	0.696

Adjusted for age, sex, education years, MMSE, APOE ε4 carrier status, BMI, cigarette use, alcohol use, and physical activity. The statistically significant results were bolded
Abbreviations: CMD Cardiometabolic disease, MMSE Mini-Mental State Examination, APOE Apolipoprotein E, BMI Body mass index

ISSN: 1758-9193