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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Fig. 2

Stratified analyses of associations between CSF AD biomarkers and CMD status. Multiple linear regression models were employed with adjustment for age, sex, education years, MMSE, APOE ε4 carrier status, BMI, cigarette use, alcohol use, and physical activity. In stratified analyses, CMD multimorbidity showed significant or suggestive associations with CSF T-tau levels in males, and APOE ε4 non-carriers. The association between hypertension and CSF AD biomarkers was found in mid-life, but not in late-life. Abbreviations: CMD, cardiometabolic disease; CSF, cerebrospinal fluid; AD, Alzheimer’s disease; MMSE, Mini-Mental State Examination; APOE ε4, apolipoprotein E; BMI, body mass index; HD, heart disease

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Alzheimer's Research & Therapy

ISSN: 1758-9193