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Table 5 ROC analysis of plasma p-tau217 for identifying abnormal CSF p-tau217 status

From: Effects of certain pre-analytical factors on the performance of plasma phospho-tau217

Plasma p-tau217

AUC (95% CI)

Sensitivity %

Specificity %

Cut-off

Youden’s Index

Cond 1: thaw at RT, NC

0.866 (0.797, 0.935)

95.1

67.8

0.282

0.629

Cond 2: thaw at RT, C

0.917 (0.864, 0.970)

92.7

83.1

0.240

0.757

Cond 3: thaw on ice, NC

0.908 (0.853, 0.964)

95.1

71.2

0.232

0.663

Cond 4: thaw on ice, C

0.924 (0.875, 0.972)

87.8

81.4

0.242

0.692

  1. Abbreviations: AUC Area under the curve, CSF Cerebrospinal fluid, C Centrifugation, Cond Condition, NC Non-centrifugation, ROC Receiver operating characteristic, RT Room temperature
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Alzheimer's Research & Therapy

ISSN: 1758-9193