Skip to main content
Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Fig. 4

CASP11 promotes unique genetic phenotype including alterations of neuroinflammatory signaling pathways in the 5xFAD hippocampus. A Heatmap showing differentially expressed genes, based on relative Z-score, in the hippocampus of 7-month-old 5xFAD (AD) and 5xFAD/Casp4−/− animals. B GO-biological process enrichment analysis and C WikiPathway enrichment analysis for the upregulated genes in 5xFAD Casp4−/− versus 5xFAD animals. D GO-biological process enrichment analysis for genes upregulated in 5xFAD versus Casp4−/− 5xFAD animals. E Volcano plot showing DEG (fold change > 1, P < 0.05) for 5xFAD/Casp4−/− vs. 5xFAD mice. Heatmaps demonstrating differentially expressed genes: F neuroinflammation signaling pathway from IPA, G IL-8 signaling pathway from IPA, and H chemokine signaling pathway from KEGG

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193