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Table 1 Baseline characteristics and distribution of the MetRS stratified by dementia status

From: Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants

Characteristics

Overall

Control

Incident dementia

Incident AD

Incident VaD

 

N = 274,160

N = 268,886

N = 5274

P

N = 2346

P

N = 1221

P

Age, year

58.00 [50.00, 63.00]

58.00 [50.00, 63.00]

65.00 [62.00, 68.00]

 < 0.001

66.00 [63.00, 68.00]

 < 0.001

66.00 [63.00, 68.00]

 < 0.001

Female

147,969 (54.0)

145,485 (54.1)

2484 (47.1)

 < 0.001

1224 (52.2)

0.064

480 (39.3)

 < 0.001

White ethnicity

259,499 (95.1)

254,429 (95.0)

5070 (96.7)

 < 0.001

2259 (96.9)

 < 0.001

1182 (97.0)

0.008

Education, year

4.00 [3.00, 8.00]

4.00 [3.00, 8.00]

3.00 [2.00, 7.00]

 < 0.001

3.00 [2.00, 7.00]

 < 0.001

3.00 [2.00, 7.00]

 < 0.001

APOE ε4, single-copy carriers

71,153 (26.2)

68,922 (25.8)

2231 (42.6)

 < 0.001

1098 (47.3)

 < 0.001

490 (40.4)

 < 0.001

APOE ε4, double-copies carriers

6529 (2.4)

5984 (2.2)

545 (10.4)

 < 0.001

322 (13.9)

 < 0.001

113 (9.3)

 < 0.001

Body mass index, Kg/m2

26.77 [24.17, 29.92]

26.76 [24.17, 29.91]

27.18 [24.52, 30.45]

 < 0.001

26.99 [24.36, 30.00]

0.153

27.96 [25.19, 31.48]

 < 0.001

Current smoker

28,853 (10.6)

28,320 (10.6)

533 (10.2)

0.386

201 (8.7)

0.003

142 (11.7)

0.214

Pairs matching time, second

188.50 [148.50, 244.50]

188.00 [148.50, 243.50]

226.50 [169.00, 314.50]

 < 0.001

231.00 [172.50, 319.00]

 < 0.001

229.50 [171.50, 325.00]

 < 0.001

Reaction time, million second

538.00 [481.00, 610.00]

536.00 [480.00, 610.00]

586.00 [520.00, 672.00]

 < 0.001

583.00 [520.00, 668.00]

 < 0.001

597.00 [532.00, 686.25]

 < 0.001

Standardized MetRS (ACD)

 − 0.18 [− 0.71, 0.39]

 − 0.18 [− 0.71, 0.38]

0.18 [− 0.30, 1.09]

 < 0.001

0.14 [− 0.33, 0.99]

 < 0.001

0.44 [− 0.19, 1.46]

 < 0.001

Standardized MetRS (AD)

 − 0.18 [− 0.63, 0.45]

 − 0.19 [− 0.63, 0.45]

0.22 [− 0.35, 0.91]

 < 0.001

0.21 [− 0.37, 0.87]

 < 0.001

0.36 [− 0.28, 1.15]

 < 0.001

Standardized MetRS (VaD)

 − 0.32 [− 0.55, 0.25]

 − 0.32 [− 0.55, 0.24]

0.05 [− 0.44, 0.84]

 < 0.001

 − 0.03 [− 0.46, 0.70]

 < 0.001

0.27 [− 0.33, 1.16]

 < 0.001

Selected metabolites

  His, mmol/L

0.06 [0.06, 0.07]

0.06 [0.06, 0.07]

0.06 [0.06, 0.07]

 < 0.001

0.06 [0.06, 0.07]

 < 0.001

0.06 [0.06, 0.07]

 < 0.001

  Leu, mmol/L

0.10 [0.08, 0.12]

0.10 [0.08, 0.12]

0.10 [0.08, 0.12]

 < 0.001

0.10 [0.08, 0.12]

 < 0.001

0.10 [0.08, 0.12]

0.808

  Total BCAA, mmol/L

0.35 [0.31, 0.41]

0.35 [0.31, 0.41]

0.35 [0.30, 0.41]

 < 0.001

0.34 [0.30, 0.40]

 < 0.001

0.36 [0.30, 0.42]

0.261

  Val, mmol/L

0.21 [0.18, 0.23]

0.21 [0.18, 0.23]

0.20 [0.18, 0.23]

 < 0.001

0.20 [0.18, 0.23]

 < 0.001

0.21 [0.18, 0.24]

0.142

  LA%

29.10 [26.74, 31.24]

29.12 [26.76, 31.25]

28.06 [25.72, 30.38]

 < 0.001

28.26 [26.12, 30.46]

 < 0.001

27.34 [24.90, 29.70]

 < 0.001

  Omega-6/Omega-3

9.01 [7.16, 11.48]

9.02 [7.16, 11.49]

8.62 [6.85, 10.91]

 < 0.001

8.54 [6.84, 10.66]

 < 0.001

8.47 [6.71, 10.67]

 < 0.001

  LA, mmol/L

3.42 [2.99, 3.88]

3.42 [2.99, 3.88]

3.28 [2.79, 3.80]

 < 0.001

3.34 [2.85, 3.85]

 < 0.001

3.18 [2.70, 3.71]

 < 0.001

  Glu, mmol/L

3.56 [3.12, 4.04]

3.56 [3.11, 4.03]

3.73 [3.26, 4.30]

 < 0.001

3.70 [3.26, 4.27]

 < 0.001

3.81 [3.32, 4.45]

 < 0.001

  IDL-C, mmol/L

0.83 [0.69, 0.98]

0.83 [0.69, 0.98]

0.79 [0.62, 0.96]

 < 0.001

0.83 [0.64, 0.99]

0.003

0.73 [0.58, 0.92]

 < 0.001

  IDL-P, mmol/L

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

 < 0.001

0.00 [0.00, 0.00]

0.003

0.00 [0.00, 0.00]

 < 0.001

  SM, mmol/L

0.45 [0.40, 0.50]

0.45 [0.40, 0.50]

0.44 [0.38, 0.50]

 < 0.001

0.45 [0.39, 0.51]

0.41

0.42 [0.37, 0.48]

 < 0.001

  IDL-CE%

50.30 [48.64, 51.66]

50.31 [48.66, 51.67]

49.62 [47.70, 51.21]

 < 0.001

49.82 [48.14, 51.35]

 < 0.001

49.14 [47.11, 50.84]

 < 0.001

  IDL-FC%

17.81 [17.07, 18.47]

17.81 [17.07, 18.47]

17.77 [16.96, 18.46]

0.002

17.83 [17.02, 18.55]

0.62

17.71 [16.80, 18.43]

 < 0.001

  L-HDL-TG%

4.78 [3.37, 6.94]

4.77 [3.37, 6.94]

5.07 [3.55, 7.29]

 < 0.001

4.96 [3.48, 7.16]

0.001

5.42 [3.68, 7.72]

 < 0.001

  S-LDL-CE%

45.90 [44.55, 47.20]

45.90 [44.55, 47.20]

45.62 [44.28, 46.98]

 < 0.001

45.70 [44.32, 47.01]

 < 0.001

45.50 [44.17, 46.84]

 < 0.001

  S-LDL-C%

63.50 [62.18, 64.57]

63.51 [62.20, 64.58]

63.00 [61.48, 64.25]

 < 0.001

63.19 [61.76, 64.38]

 < 0.001

62.60 [60.99, 64.02]

 < 0.001

  S-LDL-PL%

31.19 [30.12, 32.33]

31.18 [30.12, 32.32]

31.41 [30.34, 32.54]

 < 0.001

31.37 [30.30, 32.48]

 < 0.001

31.48 [30.39, 32.59]

 < 0.001

  1. Values are reported as median [interquartile range] for continuous variables or numbers (percentage) for categorical variables. P-values are derived using either Student’s t-test or chi-square test. Metabolites selected from three dementia type models were shown here, see all 249 metabolites baseline characters in Table S2
  2. Abbreviations: His, histidine; Leu, leucine; BCAA, branched-chain amino acids; Val, valine; LA, linoleic acid; Glu, glucose; SM, sphingomyelins; C, cholesterol; CE, cholesteryl esters; FC, free cholesterol; P, particles; PL, phospholipids; TG, triglycerides
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Alzheimer's Research & Therapy

ISSN: 1758-9193