Fig. 3

MetRS stratifies the risk of dementia onset. A–C Observed event rate for incident ACD, AD and VaD, plotted against MetRS percentiles over the entire study population. Blue dots represent males and red dots represent females. The size of each dot is proportional to age. D–F Cumulative risk over the observation time for incident ACD, AD and VaD, stratified by MetRS tertiles (light blue, bottom tertile; blue, median tertile; dark blue, top tertile). The shaded area indicates the 95% CI of the survival curves. G Regression results of MetRS and dementia outcomes in all participants and subgroups. Model 1, MetRS; Model2, MetRS + demographic indicators; Model 3, MetRS + demographic indicators + cognitive indicators. Abbreviations: ACD, all-cause dementia; AD, Alzheimer’s disease; VaD, vascular dementia