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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Associations of cerebrospinal fluid complement proteins with Alzheimer’s pathology, cognition, and brain structure in non-dementia elderly

Fig. 4

Explanatory analyses of associations between CSF complement proteins, brain structures, and cognition in MCI participants. The relationship between CSF complement proteins and cognition was mediated by ventricles (A–D), whole brain (E), fusiform gyrus (F), or middle temporal lobe (G–I). The proportions shown in the figure indicate the proportion of mediating factors in the total effect of brain structures on cognition. ADAS-13, Alzheimer’s Disease Assessment Scale-13; ADNI, Alzheimer’s Disease Neuroimaging Initiative; CDRSB, Clinical Dementia Rating Sum of Boxes; EF, executive function; LAN, language; MCI, mild cognitive impairment; MEM, memory function; MMSE, Mini-Mental State Examination

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Alzheimer's Research & Therapy

ISSN: 1758-9193