Fig. 2

Associations between baseline CSF complement proteins and longitudinal changes of CSF AD biomarkers among CN participants. The mixed effect linear models were applied adjusting for gender, age, educational level, and APOE-ε4 status. Abbreviations: APOE, apolipoprotein E; Aβ42, amyloid β peptide 42; C1q, complement C1q subcomponent subunit B; C2, complement C2; C5, complement C5; C6, complement C6; C8B, complement component C8 beta chain; CFB, complement factor B; CN, cognitively normal; CSF, cerebrospinal fluid; p-tau, phosphorylated tau, t-tau, total tau