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Table 1 Clinical diagnosis, sex, age, neuropathological assessment, bTVBT2 + microglia density and cause of death of cases included in the retina study

From: The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and AppNL−F/NL−F mice

Clinical diagnosis

Sex

Age (years)

Braak stages

(NFT/Aβ/LB)

APOE

genotype

PMD

(h:min)

Aβ40HMW

(pg/ml)

Aβ42HMW

(pg/ml)

Cause of death

NC

M

81

3/C/0

4/3

4:30

23.48

1.83

Pancreas carcinoma

NC

F

92

3/O/1

3/4

6:35

2.80

0.45

Heart failure

NC

M

75

1/A/0

3/3

7:10

29.33

4.31

Cardiac arrest

NC

M

70

1/O/3

3/2

6:20

2.85

0.19

Pneumonia

NC

M

102

3/A/0

4/3

5:00

24.16

3.09

Ileus

NC

M

55

0/O/0

3/3

7:30

12.10

0.21

Esophageal cancer

NC

F

60

0/O/0

3/2

8:10

0.67

0.07

Breast cancer

NC

F

68

1/O/0

3/3

4:30

na

na

Euthanasia

AD

F

92

6/C/0

4/3

6:10

4.91

0.92

Atrioventricular block

AD

F

70

6/C/0

4/4

4:20

8.12

1.33

Cachexia

AD

F

78

6/C/0

4/4

4:45

18.36

2.26

Cachexia

AD

F

96

4/B/0

3/3

7:20

4.78

0.34

Heart failure

AD

M

69

6/C/0

4/3

6:30

na

na

Pneumonia

AD

F

65

5/C/0

4/3

4:30

na

na

Respiratory infection

AD

F

88

5/C/5

3/3

5:40

2.28

0.27

Cachexia

AD

M

63

4/C/6

4/4

4:55

3.03

0.40

Hepatic insufficiency

AD

F

83

4/C/6

3/3

6:15

1.81

.018

Respiratory infection

  1. Cases clinically diagnosed as non-demented controls (NC) or Alzheimer’s disease (AD). Braak staging of neurofibrillary tangles (NFT), amyloid (Aβ), and Lewy bodies (LB). Female, Male. Aβ40HMW = high molecular weight amyloid beta 40. Aβ42HMW = high molecular weight amyloid beta 42. na = not analyzed due to lack of tissue