Fig. 4
bTVBT2 co-localization with tau in mouse retina. Image in A shows a confocal orthogonal view of a bTVBT2-positive signal inside an Iba1-positive retinal microglia in a 3-month-old AppNL−F/NL−F knock-in mouse. The graph in B shows that the proportion of bTVBT2-positive microglia in the retina increases significantly in 9–12-month-old AppNL−F/NL−F knock-in mice compared to 3-month-old AppNL−F/NL−F knock-in mice, whereas 12- to 18-month-old WT mice have similar levels as 3-month-old AppNL−F/NL−F knock-in mice. Data is presented as mean ± SD and was analyzed using one-way ANOVA, followed by the Tukey test with (n = 3) comparisons. Each point represents the mean of (n = 50) microglia in each group (n = 6). Significant difference at ** = p < 0.01. Scale bar in A represents 5 µm